2,2'-(2-Fluoro-1,3-phenylene)bis(4,4-dimethyl-4,5-dihydro-1,3-oxazole)

Base Information

Chemical Name:2,2'-(2-Fluoro-1,3-phenylene)bis(4,4-dimethyl-4,5-dihydro-1,3-oxazole)
CAS No.:84011-93-8
Molecular Formula:C16H19FN2O2
Molecular Weight:290.337
Hs Code.:
DSSTox Substance ID:DTXSID30529299
Wikidata:Q82399648

Synonyms:84011-93-8;DTXSID30529299;2,2'-(2-Fluoro-1,3-phenylene)bis(4,4-dimethyl-4,5-dihydro-1,3-oxazole)

Suppliers and Price of 2,2'-(2-Fluoro-1,3-phenylene)bis(4,4-dimethyl-4,5-dihydro-1,3-oxazole)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2'-(2-Fluoro-1,3-phenylene)bis(4,4-dimethyl-4,5-dihydro-1,3-oxazole)

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:290.14305602
Heavy Atom Count:21
Complexity:443

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(COC(=N1)C2=C(C(=CC=C2)C3=NC(CO3)(C)C)F)C

Technology Process of 2,2'-(2-Fluoro-1,3-phenylene)bis(4,4-dimethyl-4,5-dihydro-1,3-oxazole)

There total 3 articles about 2,2'-(2-Fluoro-1,3-phenylene)bis(4,4-dimethyl-4,5-dihydro-1,3-oxazole) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 91129-31-6
N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2-fluoro-1,3-benzenedicarboxamide

: 84011-93-8
2,2'-(2-fluoro-1,3-phenylene)bis<4,5-dihydro-4,4-dimethyl-2-oxazoline>

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00244a037

Reference yield:

: 1583-65-9
2-fluoro-isophthalic acid

: 84011-93-8
2,2'-(2-fluoro-1,3-phenylene)bis<4,5-dihydro-4,4-dimethyl-2-oxazoline>

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / SOCl₂ / dimethylformamide; benzene / 5 h / Heating

2: 81 percent / CH₂Cl₂ / 0.5 h / 0 °C

3: 93 percent / SOCl₂ / CH₂Cl₂; dimethylformamide

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00244a037

Reference yield:

: 91129-30-5
2-fluoroisophthalic acid dichloride

: 84011-93-8
2,2'-(2-fluoro-1,3-phenylene)bis<4,5-dihydro-4,4-dimethyl-2-oxazoline>

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / CH₂Cl₂ / 0.5 h / 0 °C

2: 93 percent / SOCl₂ / CH₂Cl₂; dimethylformamide

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00244a037