1583-65-9

Usage

Uses

Used in Pharmaceutical Production:
2-Fluoroisophthalic acid serves as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with improved efficacy and selectivity. Its unique chemical properties allow for the creation of novel molecular structures with potential therapeutic benefits.
Used in Agrochemical Development:
In the agrochemical industry, 2-fluoroisophthalic acid is utilized for the production of innovative compounds that can enhance crop protection and yield. Its reactivity and chemical properties enable the design of new agrochemicals with targeted pest control and reduced environmental impact.
Used in Functional Materials:
2-Fluoroisophthalic acid is employed in the creation of functional materials with specific properties, such as high thermal stability, chemical resistance, or optical characteristics. These materials find applications in various industries, including electronics, coatings, and adhesives.
Used in Biotechnology:
With its potential applications in biotechnology, 2-fluoroisophthalic acid can be used to develop new bioactive compounds or modify existing ones, enhancing their performance in biological systems.
Used in Materials Science:
In materials science, 2-fluoroisophthalic acid is a valuable component in the synthesis of advanced materials with tailored properties, such as high strength, lightweight, or self-healing capabilities.
Used in Drug Development:
As a building block in drug development, 2-fluoroisophthalic acid aids in the design and synthesis of new pharmaceutical agents with improved pharmacokinetics, potency, and selectivity.
Used in Fluorescent Dyes and Polymers Synthesis:
2-Fluoroisophthalic acid is also a crucial intermediate in the synthesis of fluorescent dyes and polymers, which have applications in imaging, sensing, and other advanced technologies.

Upstream product

• 443-88-9 2-fluoro-m-xylene 
• 21161-11-5 2-nitroisophthalic acid 
• 87-62-7 2,6-dimethylaniline 
• 81-20-9 2,6-dimethylnitrobenzene 
• 91129-30-5 2-fluoroisophthalic acid dichloride 
• 723334-03-0 2-fluoro-isophthalic acid dimethyl ester 

Downstream Products

• 640768-78-1 2-fluoroisophthalic acid monooctyl ester 
• 914301-44-3 2-fluoroisophthalic acid monomethyl ester 
• 1042055-88-8 3-amino-2-fluorobenzoic acid trifluoroacetate 
• 1042055-86-6 methyl 3-((tert-butoxycarbonyl)amino)-2-fluorobenzoate 
• 1260236-47-2 methanesulfonic acid 3-(3-ethyloxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-ylcarbamoyl)-2-fluorobenzyl ester 
• 1260236-45-0 (2-fluoro-3-(hydroxymethyl)phenyl)(piperidine-1-yl)methanone 
• 1260236-46-1 N-(3-ethoxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalene-7-yl)-2-fluoro-3-hydroxymethylbenzamide 
• 1260236-43-8 methyl 2-fluoro-3-(piperidine-1-carbonyl)benzoate 
• 481075-37-0 2-fluoro-3-(hydroxymethyl)benzoic acid 
• 1007312-09-5 C₈H₄FNO₆ 
• 91129-31-6 N,N'-bis(2-hydroxy-1,1-dimethylethyl)-2-fluoro-1,3-benzenedicarboxamide 
• 107913-60-0 C₂₄H₂₈N₂O₂ 
• 84011-94-9 2,2'(3'-methyl<1,1'-biphenyl>2,6-diyl)bis(4,5-dihydro-4,4-dimethyloxazole) 
• 105373-36-2 38-(3,5-Dimethylphenyl)-7,8,19,20,28,29,35,36-octahydro-6H,10H,16H,18H,32H,34H-59:17,21-dimethano-11,15-metheno-1,2,5-<1',3'>pyrimidino-5H,27H-dibenzo<1,23,4,8,16,20>dioxatetraazacyclohexacosine-32,37,39-trione 

Relevant academic research and scientific papers

Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus

Inhibition of the protein chaperone Hsp90 is a promising new approach to cancer therapy. We describe the preparation of potent non-benzoquinone ansamycins. One of these analogues, generated by feeding 3-amino-5-chlorobenzoic acid to a genetically engineer

Conformational flexibility of tetralactam macrocycles and their intermolecular hydrogen-bonding patterns in the solid state

Despite their rigid scaffold, tetralactam macrocycles (TLMs) display a remarkable degree of conformational flexibility, as revealed by analysis of the corresponding X-ray crystal structures. This flexibility is not limited to the rotatability of the TLM amide groups but also applies to the m-xylene rings, and it thus has a great impact on the overall shape of the macrocycle cavity. The conformational properties of the TLMs give rise to a broad variety of intermolecular hydrogen-bonding patterns, including infinite ladders, an interesting catemer motif, and short C-H... O=C hydrogen bonds. These results are in accord with previous theoretical calculations, support a structural model proposed earlier for an interpretation of scanning tunneling microscopy images, and substantially contribute to the understanding of the adaptability of macrocyclic scaffolds, which is crucial for guest binding or templated syntheses with TLMs.

Macrolactams by engineered biosynthesis

Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynt

Design, synthesis, and incorporation of a β-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT1 and AT2 receptors

A benzodiazepine-based β-turn mimetic has been designed, synthesized, and incorporated into angiotensin II. Comparison of the mimetic with β-turns in crystallized proteins showed that it most closely resembles a type II β-turn. The compounds exhibited hig

A lockable light-driven molecular shuttle with a fluorescent signal

A turn on! A lockable photodriven molecular shuttle is based on a [2]rotaxane that consists of an α-cyclodextrin threaded by a stilbene derivative. The fluorescent signals originate from the naphthalimide stopper and indicate the position of the shuttle. Once unlocked, the device can be turned on by irradiation at 335 nm and turned off by irradiation at 280 nm. The shuttle can be locked or unlocked by the addition acid or alkali, respectively (see picture).

Hydrazide-Based Quadruply Hydrogen-Bonded Heterodimers. Structure, Assembling Selectivity, and Supramolecular Substitution

This paper describes the synthesis, self-assembly, and characterization of a new class of highly stable hydrazide-based quadruply hydrogen-bonded heterodimers. All of the hydrazide-derived heterodimers possess the complementary ADDA-DAAD hydrogen-bonding sequences. Hydrazide derivatives 1, which has two intramolecular S(6) RO...H-N hydrogen bonds, and 2 complex to afford two fastly exchanging isomeric heterodimers 1·2 and 1·2′ in chloroform, as a result of two different conformational arrangements of 2. An average binding constant Kassoc of 4.7 × 104 M-1 was determined for heterodimer 1·2 and 1·2′ by 1H NMR titration of 1 with changing 2 in chloroform-d. In contrast, 1 binds 11 and 12, both of which are introduced with two intramolecular S(6) hydrogen bonds, to exclusively afford heterodimers 1·11 and 1·12, with Kassoc values of 1.8 × 104 and 5.0 × 102 M-1, respectively. Fluorine-containing 19, which has a hydrazide skeleton identical to that of 1 but two intramolecular S(6) F...H-N hydrogen bonds, can also complex with 2, 11, and 12, to afford heterodimers 19·2, 19·2′, 19·11, and 19·12, with Kassoc values of of 1.2 × 104 (average value for 19·2 and 19·2′), 5.4 × 103, and 1.9 × 102 M-1, respectively. The structures of the new heterodimers have been proven with NOESY, IR, and VPO (for some of the heterodimers) experiments. Moreover, 1 and 19 can also strongly bind 2,7-dilauroylamido-1,8-naphthyridine 23 to afford dimers 1·23 and 19·23 with Kassoc values of 6.0 × 105 and 1.4 × 105 M-1, respectively. Adding 1 to the 1:1 solution of 23 and 1-octyl-3-(4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl)urea 24 or 1-octyl-3-(4-oxo-1,4-dihydropyrimidin-2-yl)urea 25, which had been developed initially by Zimmerman and Meijer, respectively, induces dimers 23·24 and 23·25 to dissociate, leading to the formation of dimers 1·23 and 24·24 or 25·25, respectively. The new hydrazide-based hydrogen-bonding modules described are useful building blocks for self-assembly and open a new avenue to recognition between discrete supramolecular species.