5(4H)-Oxazolone, 2-(2-bromophenyl)-4-[(4-methoxyphenyl)methylene]-

Base Information

Chemical Name:5(4H)-Oxazolone, 2-(2-bromophenyl)-4-[(4-methoxyphenyl)methylene]-
CAS No.:84156-18-3
Molecular Formula:C₁₇H₁₂BrNO₃
Molecular Weight:358.191
Hs Code.:
DSSTox Substance ID:DTXSID60390994

Synonyms:DTXSID60390994;5(4H)-Oxazolone, 2-(2-bromophenyl)-4-[(4-methoxyphenyl)methylene]-

Suppliers and Price of 5(4H)-Oxazolone, 2-(2-bromophenyl)-4-[(4-methoxyphenyl)methylene]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5(4H)-Oxazolone, 2-(2-bromophenyl)-4-[(4-methoxyphenyl)methylene]-

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:357.00006
Heavy Atom Count:22
Complexity:480

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C=C2C(=O)OC(=N2)C3=CC=CC=C3Br

Technology Process of 5(4H)-Oxazolone, 2-(2-bromophenyl)-4-[(4-methoxyphenyl)methylene]-

There total 4 articles about 5(4H)-Oxazolone, 2-(2-bromophenyl)-4-[(4-methoxyphenyl)methylene]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 103205-37-4
(Z)-2-Amino-3-(4-methoxy-phenyl)-acrylic acid

: 6630-33-7
ortho-bromobenzaldehyde

: 84156-18-3
4-(4-methoxybenzylidene)-2-(2-bromophenyl)-5(4H)-oxazolone

Guidance literature:: With sodium acetate; acetic anhydride;

Reference yield:

: 7154-66-7
2-bromobenzoic acid chloride

: 84156-18-3
4-(4-methoxybenzylidene)-2-(2-bromophenyl)-5(4H)-oxazolone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / 2-methyltetrahydrofuran; water / 0.5 h / Cooling

1.2: 3 h / 10 °C / Cooling

2.1: water; sodium hydroxide / 2-methyltetrahydrofuran / 1 h / 25 - 28 °C

3.1: sodium acetate; acetic anhydride / 2-methyltetrahydrofuran / 24 h / Reflux

With water; sodium acetate; acetic anhydride; sodium hydrogencarbonate; sodium hydroxide; In 2-methyltetrahydrofuran; water; 1.2: Schotten-Baumann reaction / 3.1: Erlenmeyer-Plochl reaction;
DOI:10.1021/op100032s

Reference yield:

: 207864-20-8
ethyl N-(o-bromobenzoyl)aminoacetate

: 84156-18-3
4-(4-methoxybenzylidene)-2-(2-bromophenyl)-5(4H)-oxazolone

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / 2-methyltetrahydrofuran / 1 h / 25 - 28 °C

2: sodium acetate; acetic anhydride / 2-methyltetrahydrofuran / 24 h / Reflux

With water; sodium acetate; acetic anhydride; sodium hydroxide; In 2-methyltetrahydrofuran; 2: Erlenmeyer-Plochl reaction;
DOI:10.1021/op100032s