2-amino-6-(4-ethoxyphenyl)-4-(4-propoxyphenyl)pyridine-3-carbonitrile

Base Information

• Chemical Name: 2-amino-6-(4-ethoxyphenyl)-4-(4-propoxyphenyl)pyridine-3-carbonitrile
• CAS No.: 6958-22-1
• Molecular Formula: C12H18 N3 O . Cl
• Molecular Weight: 255.747
• Mol file: 6958-22-1.mol

Synonyms:Ammonium,(carboxymethyl)trimethyl-, chloride, benzylidenehydrazide (8CI); Ethanaminium,N,N,N-trimethyl-2-oxo-2-[(phenylmethylene)hydrazino]-, chloride (9CI)

Chemical Property of 2-amino-6-(4-ethoxyphenyl)-4-(4-propoxyphenyl)pyridine-3-carbonitrile

Chemical Property:

• Vapor Pressure: 1.77E-13mmHg at 25°C
• Boiling Point: 580.7°Cat760mmHg
• Flash Point: 305°C
• Density: 1.21g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-6-(4-ethoxyphenyl)-4-(4-propoxyphenyl)pyridine-3-carbonitrile

There total 5 articles about 2-amino-6-(4-ethoxyphenyl)-4-(4-propoxyphenyl)pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

diisopropyl (2-((4-methoxybenzyl)amino)-2-oxoethyl)phosphonate (1426294-38-3) + girard's reagent T (123-46-6) + benzaldehyde (100-52-7) → C17H17NO2 (349426-61-5) + di-isopropylphosphonate anion + 2-(2-benzylidenehydrazinyl)-N,N,N-trimethyl-2-oxoethaneaminium chloride (6958-22-1)

Guidance literature:

diisopropyl (2-((4-methoxybenzyl)amino)-2-oxoethyl)phosphonate; benzaldehyde; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 6h;

girard's reagent T; In tetrahydrofuran; methanol; stereoselective reaction;

DOI:10.1021/co400003d

Reference yield:

girard's reagent T (123-46-6) + benzaldehyde (100-52-7) → 2-(2-benzylidenehydrazinyl)-N,N,N-trimethyl-2-oxoethaneaminium chloride (6958-22-1)

Guidance literature:

oxonium; In water; at 25 ℃; Rate constant; Equilibrium constant; Mechanism; analogous reaction with different acids as catalysts;

DOI:10.1021/jo00004a016

Reference yield:

C11H14N2O3 + girard's reagent T (123-46-6) → 2-(2-hydroxyethoxy)acetohydrazide (51707-41-6) + 2-(2-benzylidenehydrazinyl)-N,N,N-trimethyl-2-oxoethaneaminium chloride (6958-22-1)

Guidance literature:

at 25 ℃; pH=7.8; pH-value; Kinetics;

DOI:10.1039/c9ob00058e

upstream raw materials:

girard's reagent T

benzaldehyde

diisopropyl (2-((4-methoxybenzyl)amino)-2-oxoethyl)phosphonate

Downstream raw materials:

girard's reagent T

benzaldehyde