(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID

Base Information

Chemical Name:(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
CAS No.:844639-57-2
Molecular Formula:C₂₁H₂₁FN₂O₄S
Molecular Weight:416.473
Hs Code.:
Mol file:844639-57-2.mol

Synonyms:3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID;

Suppliers and Price of (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
TM30089 ≥98% (HPLC)
5MG
$ 129.00

Sigma-Aldrich
TM30089 ≥98% (HPLC)
25MG
$ 519.00

DC Chemicals
TM30089 >98%
250 mg
$ 750.00

DC Chemicals
TM30089 >98%
1 g
$ 1500.00

DC Chemicals
TM30089 >98%
100 mg
$ 375.00

ChemScene
CAY10471Racemate 99.35%
25mg
$ 290.00

ChemScene
CAY10471Racemate 99.35%
5mg
$ 90.00

ChemScene
CAY10471Racemate 99.35%
10mg
$ 140.00

Biorbyt Ltd
TM30089 >98%
1000 mg
$ 2245.70

Biorbyt Ltd
TM30089 >98%
250 mg
$ 1133.90

Total 11 raw suppliers

Chemical Property of (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID

Chemical Property:

Melting Point:165-173℃ (dichloromethane )
Boiling Point:639.1±65.0 °C(Predicted)
PKA:4.33±0.10(Predicted)
PSA：87.99000
Density:1.41±0.1 g/cm3(Predicted)
LogP:4.12380

Purity/Quality:

99.3% ^*data from raw suppliers

TM30089 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID

There total 7 articles about (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 844639-55-0
ethyl {3-[(4-fluorobenzenesulfonyl)methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl}acetate

: 844639-57-2
TM₃₀₀₈₉

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jm049036i

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 844639-57-2
TM₃₀₀₈₉

Guidance literature:: Multi-step reaction with 2 steps

1: 0.92 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 34 percent / aq. LiOH / tetrahydrofuran / 12 h / 20 °C

With lithium hydroxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm049036i

Reference yield:

: 54621-12-4
1,2,4,9-tetrahydrospiro[3H-carbazole-3,2*-[1,3]doxolane]

: 844639-57-2
TM₃₀₀₈₉

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 1 h / 20 °C

1.2: 88 percent / dimethylformamide / 12 h / 20 °C

2.1: 83 percent / aq. HCl / tetrahydrofuran / 16 h / 20 °C

3.1: AcOH / ethanol / 0.25 h / 20 °C

3.2: NaBH₃CN / ethanol / 20 °C

4.1: 0.92 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

5.1: 34 percent / aq. LiOH / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; lithium hydroxide; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049036i