Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl)phenyl]ethyl]amino]-4-methyl-, (2S)-

Base Information

Chemical Name:Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl)phenyl]ethyl]amino]-4-methyl-, (2S)-
CAS No.:847359-01-7
Molecular Formula:C24H34BF2N3O3
Molecular Weight:461.36
Hs Code.:

Pentanamide,
N-(1-cyanocyclopropyl)-2-[[(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1,
3,2-dioxaborolan-2-yl)phenyl]ethyl]amino]-4-methyl-, (2S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl)phenyl]ethyl]amino]-4-methyl-, (2S)-

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Technology Process of Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl)phenyl]ethyl]amino]-4-methyl-, (2S)-

There total 1 articles about Pentanamide, N-(1-cyanocyclopropyl)-2-[[(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1, 3,2-dioxaborolan-2-yl)phenyl]ethyl]amino]-4-methyl-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603142-88-7
N²-[(1S)-1-(4-bromophenyl)-2,2-difluoroethyl]-N¹-(1-cyanocyclopropyl)-L-leucinamide

: 73183-34-3
bis(pinacol)diborane

: 847359-01-7
N₁-(1-cyanocyclopropyl)-N₂-{(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}-L-leucinamide

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 16h;

Reference yield:

: 847359-01-7
N₁-(1-cyanocyclopropyl)-N₂-{(1S)-2,2-difluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}-L-leucinamide

: 345965-52-8
1-(4-bromophenyl)cyclopropanecarboxylic acid

: N¹-(1-cyanocyclopropyl)-N²-{(1S)-2,2-difluoro-1-{4'-[1-(carboxy)cyclopropyl]biphenyl-4-yl}-ethyl}-L-leucinamide

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); water; at 120 ℃; for 0.138889h; Microwave irradiation;