1,3-Cyclopentanediamine, N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)- 2H-pyrazolo[3,4-d]pyrimidin-4-yl]-, (1S,3S)-

Base Information

Chemical Name:1,3-Cyclopentanediamine, N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)- 2H-pyrazolo[3,4-d]pyrimidin-4-yl]-, (1S,3S)-
CAS No.:847417-35-0
Molecular Formula:C24H30F2N6O
Molecular Weight:456.539
Hs Code.:

1,3-Cyclopentanediamine,
N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)-
2H-pyrazolo[3,4-d]pyrimidin-4-yl]-, (1S,3S)-

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Chemical Property of 1,3-Cyclopentanediamine, N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)- 2H-pyrazolo[3,4-d]pyrimidin-4-yl]-, (1S,3S)-

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Technology Process of 1,3-Cyclopentanediamine, N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)- 2H-pyrazolo[3,4-d]pyrimidin-4-yl]-, (1S,3S)-

There total 9 articles about 1,3-Cyclopentanediamine, N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)- 2H-pyrazolo[3,4-d]pyrimidin-4-yl]-, (1S,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5399-92-8
4-chloro-1H-pyrazolo[3,4-d]pyrimidine

: 847417-35-0
(1S,3S)-N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]cyclopentane-1,3-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 0.25 h / 150 °C / Irradiation

With N-ethyl-N,N-diisopropylamine; In acetonitrile; butan-1-ol;

Reference yield:

: 847448-60-6
4-chloro-2-(tetrahydro-pyran-2-yl)-2H-pyrazolo[3,4-d]pyrimidine

: 847417-34-9
(1S,3S)-N-[2,2-difluoro-2-(4-methylphenyl)ethyl]cyclopentane-1,3-diamine

: 847417-35-0
(1S,3S)-N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]cyclopentane-1,3-diamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 150 ℃; for 0.25h; Irradiation;

Reference yield:

: (1S,3S)-3-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid

: 847417-35-0
(1S,3S)-N-[2,2-difluoro-2-(4-methylphenyl)ethyl]-N'-[2-(tetrahydro-2H-pyran-2-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-yl]cyclopentane-1,3-diamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 90 °C

1.2: 16 h

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 1861.78 Torr

3.1: ethanol / 16 h / Heating / reflux

4.1: hydrogenchloride / ethyl acetate / 1 h

4.2: SCX ion exchange resin

5.1: borane / tetrahydrofuran / 1 h / 0 - 70 °C

5.2: 16 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 0.25 h / 150 °C / Irradiation

With hydrogenchloride; diphenyl phosphoryl azide; borane; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; toluene; butan-1-ol;