uridine diphosphate 2-deoxyglucose

Base Information

• Chemical Name: uridine diphosphate 2-deoxyglucose
• CAS No.: 6659-40-1
• Molecular Formula: C15H24N2O16P2
• Molecular Weight: 550.3024
• Mol file: 6659-40-1.mol

Synonyms:2’-deoxy-uridine-5’-diphospho-α-D-glucopyranoside;2'-Desoxyuridin-diphosphat-glucose;dUDP-Glc;diphosphoric acid 1-(2'-deoxy-uridin-5'-yl) ester 2-D-glucopyranosyl ester;2'-deoxyuridine-5'-(α-D-glucopyranosyl)diphosphate;

Chemical Property of uridine diphosphate 2-deoxyglucose

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 296.38000
• Density: 1.9g/cm³
• LogP: -3.76450

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of uridine diphosphate 2-deoxyglucose

There total 2 articles about uridine diphosphate 2-deoxyglucose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2'-deoxyuridine-5'-triphosphate (1173-82-6,94234-60-3) + α-D-glucopyranosyl-1-phosphate (59-56-3,27251-84-9,63779-58-8,262856-84-8) → dUDP-Glc (6659-40-1)

Guidance literature:

With Glucose-1-phosphate thymidylyltransferase from Streptococcus pneumonia serotype 23F; magnesium chloride; at 37 ℃; for 1h; Enzymatic reaction;

DOI:10.1039/d0ra05799a

Reference yield: 49.0%

2’-deoxyuridine 5’-monophosphate disodium salt (42155-08-8,61240-12-8,68982-99-0) + Sucrose (57-50-1) → dUDP-Glc (6659-40-1)

Guidance literature:

With bovine serum albumine; adenosine-5'-triphosphate Na salt; tris hydrochloride; phosphoenolpyruvic acid monosodium salt; magnesium chloride; diothiothreitol; at 37 ℃; for 4h; sucrose synthase, pyruvate kinase, nucleoside monophosphate kinase;

DOI:10.1016/0040-4020(95)01081-5

upstream raw materials:

2’-deoxyuridine 5’-monophosphate disodium salt

Sucrose

2'-deoxyuridine-5'-triphosphate

α-D-glucopyranosyl-1-phosphate

Refernces

• 1、 Fang, Junqiang,Xue, Mengyang,Gu, Guofeng,Liu, Xian-Wei,Wang, Peng George. "A chemoenzymatic route to synthesize unnatural sugar nucleotides using a novel N-acetylglucosamine-1-phosphate pyrophosphorylase from Camphylobacter jejuni NCTC 11168". supporting information. p. 4303 - 4307. Retrieved 2013/07/26.
• 2、 Fang, Junqiang,Guan, Wanyi,Cai, Li,Gu, Guofeng,Liu, Xianwei,Wang, Peng George. "Systematic study on the broad nucleotide triphosphate specificity of the pyrophosphorylase domain of the N-acetylglucosamine-1-phosphate uridyltransferase from Escherichia coli K12". supporting information; experimental part. p. 6429 - 6432. Retrieved 2010/06/11.