9-Methyl-9H-carbazol-3-amine

Base Information

• Chemical Name: 9-Methyl-9H-carbazol-3-amine
• CAS No.: 61166-04-9
• Molecular Formula: C13H12N2
• Molecular Weight: 196.252
• UNII: WZQ2F58W2D
• DSSTox Substance ID: DTXSID10210057
• Nikkaji Number: J833.287H
• Wikidata: Q83084612
• Mol file: 61166-04-9.mol

Synonyms:9-Methyl-9H-carbazol-3-amine;9-methylcarbazol-3-amine;61166-04-9;9-Methyl-3-aminocarbazole;9H-Carbazol-3-amine, 9-methyl-;WZQ2F58W2D;CCRIS 8646;UNII-WZQ2F58W2D;3-amino-9-methyl-carbazole;SCHEMBL728256;3-amino-9-methyl-9H-carbazol;DTXSID10210057;AKOS006345027;LS-51668;CS-0300847;EN300-236134;F2135-0345;Z1201621364

Chemical Property of 9-Methyl-9H-carbazol-3-amine

Chemical Property:

• Vapor Pressure: 4.13E-07mmHg at 25°C
• Melting Point: 174 °C
• Boiling Point: 415.4°Cat760mmHg
• PKA: 4.99±0.30(Predicted)
• Flash Point: 205°C
• PSA: 30.95000
• Density: 1.2g/cm³
• LogP: 3.49490
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 196.100048391
• Heavy Atom Count: 15
• Complexity: 241

Purity/Quality:

97% ^*data from raw suppliers

9-METHYL-9H-CARBAZOL-3-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=C(C=C(C=C2)N)C3=CC=CC=C31

Technology Process of 9-Methyl-9H-carbazol-3-amine

There total 9 articles about 9-Methyl-9H-carbazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

9-methyl-3-nitro-9H-carbazole (61166-05-0) → 3-amino-N-methylcarbazole (61166-04-9)

Guidance literature:

With hydrazine hydrate; palladium on activated charcoal; In ethanol; for 2h; Heating;

DOI:10.1071/CH01017

Reference yield: 80.0%

N,N'-dimethyl-N,N'-diphenyl-1,4-phenylenediamine (17754-68-6) → 3-amino-N-methylcarbazole (61166-04-9)

Guidance literature:

With hydrogenchloride; tin; In ethanol; for 2h; Heating;

DOI:10.1080/00397919608004606

Reference yield: 61.0%

C13H10LiN → 3-amino-N-methylcarbazole (61166-04-9)

Guidance literature:

C₁₃H₁₀LiN; With copper(I) chloride bis(lithium chloride) complex; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

With 3,3’-di-tert-butyl oxaziridine; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/jacs.6b12712

upstream raw materials:

9-methyl-3-nitro-9H-carbazole

N,N'-dimethyl-N,N'-diphenyl-1,4-phenylenediamine

N-methylcarbazole

9H-carbazole

Downstream raw materials:

N-(9-methyl-carbazol-3-yl)-acetamide

o-Hydroxyphenyl-N-(3-N-methylcarbazolyl)azomethine

7-methyl-1,3-diphenyl-7H-pyrido[2,3-c]carbazole

Refernces

• 1、 Kim, Jiseon,Jung, Sang-Hyuk,Yun, Eunju,Cho, Soo-Hyun,Yuseok,Kim, Ji-Eun,Kim, Young-Ho,Myung, Chang-Seon,Song, Gyu-Yong. "Synthesis of Novel 3-N-substituted Carbazole Derivatives and Evaluation of their Abilities to Inhibit Platelet Aggregation". supporting information. p. 726 - 728. Retrieved 2018/05/14.
• 2、 -. "1-CYANO-PYRROLIDINE DERIVATIVES AS INHIBITORS OF USP30.". Page/Page column 62; 63. . Retrieved 2018/02/03.