9-Methylcarbazole

Base Information

• Chemical Name: 9-Methylcarbazole
• CAS No.: 1484-12-4
• Molecular Formula: C13H11 N
• Molecular Weight: 181.237
• Hs Code.: 2933990090
• European Community (EC) Number: 216-054-5
• NSC Number: 121195
• UNII: 76SOP090PG
• DSSTox Substance ID: DTXSID1073945
• Nikkaji Number: J86.513C
• Wikidata: Q27266509
• ChEMBL ID: CHEMBL1908211
• Mol file: 1484-12-4.mol

Synonyms:9-methylcarbazole;N-methylcarbazole

Chemical Property of 9-Methylcarbazole

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.000102mmHg at 25°C
• Melting Point: 90 - 92 C
• Refractive Index: 1.6191 (estimate)
• Boiling Point: 337.8°Cat760mmHg
• Flash Point: 158.1°C
• PSA: 4.93000
• Density: 1.09g/cm³
• LogP: 3.33150
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 181.089149355
• Heavy Atom Count: 14
• Complexity: 191

Purity/Quality:

97% ^*data from raw suppliers

9-Methyl-9H-carbazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-41-50/53
• Safety Statements: 26-39-60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2C3=CC=CC=C31

Technology Process of 9-Methylcarbazole

There total 169 articles about 9-Methylcarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

9H-carbazole (86-74-8,105184-46-1,97960-57-1) + methyl iodide (74-88-4) → N-methylcarbazole (1484-12-4)

Guidance literature:

9H-carbazole; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide;

Reference yield: 99.0%

trifluoroacetic acid-methyl ester (431-47-0) + 9H-carbazole (86-74-8,105184-46-1,97960-57-1) → N-methylcarbazole (1484-12-4)

Guidance literature:

9H-carbazole; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

trifluoroacetic acid-methyl ester; In N,N-dimethyl-formamide; for 10h;

Reference yield: 99.0%

9H-carbazole (86-74-8,105184-46-1,97960-57-1) + carbonic acid dimethyl ester (616-38-6) → N-methylcarbazole (1484-12-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 90 ℃; for 7h; Further Variations:; Temperatures; Solvents; Pressures; Reagents; reaction times; microwave irradiation; Product distribution;

DOI:10.1021/ol016949n

upstream raw materials:

9-methyl-2,3,4,9-tetrahydro-1H-carbazole

9-carbazolylacetic acid

carbazole-1-carboxylic acid methyl ester

1-Cyanonaphthalene

Downstream raw materials:

N-Methyl-1,2,3,4,5,6,7,8-octahydrocarbazol

9-methyl-2,3,4,9-tetrahydro-1H-carbazole

3-amino-N-methylcarbazole

2-(N-methylamino)-1,1'-biphenyl

Refernces

5-Deoxy glycofuranosides by carboxyl group assisted photoinduced electron-transfer deoxygenation

10.1016/j.tet.2007.12.005

The research focuses on the development of practical methods for the synthesis of deoxy sugars, specifically 5-deoxy-glycofuranosides, through a photoinduced electron-transfer (PET) reaction using 9-methylcarbazole (MCZ) as a photosensitizer. The study aimed to improve upon existing methods by utilizing the carboxylic group's assistance in the deoxygenation process, which significantly reduced the required irradiation time. The researchers applied this method to derivatives of D-galacturonic acid and D-glucofuranosidurono-6,3-lactone, successfully synthesizing 5-deoxy-galacto and glucofuranosides. The conclusions of the research highlighted the efficiency of the PET deoxygenation method, the selectivity for the reduction at the α-carbonyl position, and the potential of this approach to avoid the use of metal hydrides, thus offering a more environmentally friendly alternative for the synthesis of deoxy sugars, which are important for enzymatic characterization and the synthesis of natural products from carbohydrate precursors.