LenalidoMide (heMihydrate)

Base Information

• Chemical Name: LenalidoMide (heMihydrate)
• CAS No.: 847871-99-2
• Molecular Formula: C₁₃H₁₃N₃O₃*0H₂O
• Molecular Weight: 268.272
• Mol file: 847871-99-2.mol

Synonyms:Lenalidomide hemihydrate;UNII-XQT0NAW8WD;

Chemical Property of LenalidoMide (heMihydrate)

Chemical Property:

• PSA: 201.21000
• LogP: 1.58530

Purity/Quality:

99% ^*data from raw suppliers

Lenalidomidehemihydrate 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of LenalidoMide (heMihydrate)

There total 2 articles about LenalidoMide (heMihydrate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-NT (19171-18-7) → 3-(4-amino-1-oxo-1,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione hemihydrate (847871-99-2)

Guidance literature:

4-NT; With dimethyl sulfoxide; at 45 - 55 ℃;

With water; at 0 - 20 ℃; Temperature;

Reference yield:

Lenalidomide (879126-98-4,879126-99-5,191732-72-6) → 3-(4-amino-1-oxo-1,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione hemihydrate (847871-99-2)

Guidance literature:

In methanol; water; at 0 - 50 ℃;

Reference yield:

3-(4-amino-1-oxo-1,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione hemihydrate (847871-99-2) + 3,5-Dihydroxybenzoic acid (99-10-5) → C13H13N3O3*C7H6O4 (1608889-64-0)

Guidance literature:

In ethanol; at 20 ℃; Milling;

DOI:10.1021/cg500327s

upstream raw materials:

Lenalidomide

4-NT

Downstream raw materials:

C₁₃H₁₃N₃O₃*C₇H₆O₄

Refernces

• 1、 -. "A CRYSTALLINE FORM OF LENALIDOMIDE AND A PROCESS FOR ITS PREPARATION". Page/Page column 18-19. . Retrieved 2010/06/17.