2,6-Piperidinedione, 3-phenyl-

Base Information

• Chemical Name: 2,6-Piperidinedione, 3-phenyl-
• CAS No.: 14149-34-9
• Molecular Formula: C11H11 N O2
• Molecular Weight: 189.2105
• UNII: 3T25LKQ6TX
• DSSTox Substance ID: DTXSID20931105
• Nikkaji Number: J75.664D
• Mol file: 14149-34-9.mol

Synonyms:alpha-phenylglutarimide

Chemical Property of 2,6-Piperidinedione, 3-phenyl-

Chemical Property:

• Vapor Pressure: 2.31E-06mmHg at 25°C
• Boiling Point: 392.3°Cat760mmHg
• Flash Point: 176.6°C
• PSA: 46.17000
• Density: 1.185g/cm³
• LogP: 1.53560
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 189.078978594
• Heavy Atom Count: 14
• Complexity: 244

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)NC(=O)C1C2=CC=CC=C2

Technology Process of 2,6-Piperidinedione, 3-phenyl-

There total 11 articles about 2,6-Piperidinedione, 3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl 4-cyano-4-phenylbutanoate (19748-87-9) → 3-phenyl-2,6-piperidine-dione (14149-34-9)

Guidance literature:

With sulfuric acid; acetic acid; for 18h; Reflux;

DOI:10.1002/adsc.202000230

Reference yield: 46.0%

6-t-butylamino-5-phenyl-4,5-dihydro-3H-pyridin-2-one (860621-32-5) → 3-phenyl-2,6-piperidine-dione (14149-34-9)

Guidance literature:

With acetic acid; In 1,4-dioxane; water; for 50h; Heating;

DOI:10.1002/jhet.5570420417

Reference yield: 24.0%

2-phenylpentanedinitrile (91137-66-5) → 3-phenyl-2,6-piperidine-dione (14149-34-9)

Guidance literature:

With sulfuric acid; acetic acid; for 6h;

DOI:10.1021/jm00158a007

upstream raw materials:

2-phenylglutaric acid

methyl 4-cyano-4-phenylbutanoate

2-phenylpentanedinitrile

6-t-butylamino-5-phenyl-4,5-dihydro-3H-pyridin-2-one

Downstream raw materials:

3-(4-nitrophenyl)piperidine-2,6-dione

3-(4-Amino-phenyl)-piperidine-2,6-dione

(RS)-3-phenylpiperidin-2-one