3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dichlorophenyl)methyl]-, ethyl ester

Base Information

Chemical Name:3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dichlorophenyl)methyl]-, ethyl ester
CAS No.:848081-12-9
Molecular Formula:C14H13Cl2NO2S
Molecular Weight:330.23000
Hs Code.:

Synonyms:Ethyl 2-amino-5-(2,4-dichlorobenzyl)thiophene-3-carboxylate;

Suppliers and Price of 3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dichlorophenyl)methyl]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl2-amino-5-(2,4-dichlorobenzyl)thiophene-3-carboxylate 95+%
1g
$ 491.00

Chemenu
ethyl2-amino-5-(2,4-dichlorobenzyl)thiophene-3-carboxylate 95%
1g
$ 464.00

Arctom
Ethyl2-amino-5-(2,4-dichlorobenzyl)thiophene-3-carboxylate ≥95%
1g
$ 401.00

Alichem
Ethyl2-amino-5-(2,4-dichlorobenzyl)thiophene-3-carboxylate
1g
$ 401.00

Total 2 raw suppliers

Chemical Property of 3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dichlorophenyl)methyl]-, ethyl ester

Chemical Property:

Boiling Point:457.6±45.0 °C(Predicted)
PSA：80.56000
Density:1.382±0.06 g/cm3(Predicted)
LogP:4.98580

Purity/Quality:

98% ^*data from raw suppliers

Ethyl2-amino-5-(2,4-dichlorobenzyl)thiophene-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dichlorophenyl)methyl]-, ethyl ester

There total 2 articles about 3-Thiophenecarboxylic acid, 2-amino-5-[(2,4-dichlorophenyl)methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 98581-93-2
3-(2',4'-dichlorophenyl)propionaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 848081-12-9
2-amino-5-(2',4'-dichlorobenzyl)thiophene-3-carboxylic acid ethyl ester

Guidance literature:: With sulfur; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1002/jhet.5570410613

Reference yield:

: 29898-32-6
2,4-dichloro-1-iodo-benzene

: 848081-12-9
2-amino-5-(2',4'-dichlorobenzyl)thiophene-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / palladium diacetate; aq. tetrabutylammonium chloride; sodium bicarbonate / 30 h / 80 °C

2: 35 percent / triethylamine; sulfur powd. / dimethylformamide / 2 h / 20 °C

With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; sulfur; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570410613