1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene

Base Information

• Chemical Name: 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene
• CAS No.: 848360-85-0
• Molecular Formula: C8H6BrF3O2
• Molecular Weight: 271.034
• Hs Code.: 2909309090
• Mol file: 848360-85-0.mol

Synonyms:1-bromo-2-methoxy-4-trifluoromethoxy-benzene;PC1574;

Chemical Property of 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene

Chemical Property:

• Boiling Point: 218.2±35.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.594±0.06 g/cm3(Predicted)
• LogP: 3.35630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

1-Bromo-2-methoxy-4-(trifluoromethoxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene

There total 3 articles about 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-5-(trifluoromethyloxy)phenol (205371-26-2) + methyl iodide (74-88-4) → 1-bromo-2-methoxy-4-(trifluoromethoxy)benzene (848360-85-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

2-bromo-5-(trifluoromethyloxy)phenol (205371-26-2) + dimethyl sulfate (77-78-1) → 1-bromo-2-methoxy-4-(trifluoromethoxy)benzene (848360-85-0)

Guidance literature:

2-bromo-5-(trifluoromethyloxy)phenol; With sodium hydroxide; In water; toluene; at 1 - 10 ℃; for 0.333333h;

dimethyl sulfate; With tetrabutylammomium bromide; In water; toluene; at 12 - 15 ℃;

Reference yield:

3-(trifluoromethoxy)phenol (827-99-6) → 1-bromo-2-methoxy-4-(trifluoromethoxy)benzene (848360-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / dichloromethane / 2 h / 5 - 10 °C

2.1: sodium hydroxide / water; toluene / 0.33 h / 1 - 10 °C

2.2: 12 - 15 °C

With sodium hydroxide; bromine; In dichloromethane; water; toluene;

upstream raw materials:

2-bromo-5-(trifluoromethyloxy)phenol

dimethyl sulfate

3-(trifluoromethoxy)phenol

methyl iodide

Downstream raw materials:

2-methoxy-4-trifluoromethoxybenzeneboronic acid

C₂₁H₂₅BrF₃N₃O₂

2-methoxy-4-(trifluoromethoxy)phenol

Refernces

• 1、 -. "Selective sodium channel regulator as well as preparation and application thereof". Paragraph 0094-0098. . Retrieved 2021/02/10.
• 2、 -. "ESTERS AND CARBAMATES AS MODULATORS OF SODIUM CHANNELS". Paragraph 00358. . Retrieved 2020/07/25.