2-Propenoic acid, 3-(methoxyphenyl)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(methoxyphenyl)-
• CAS No.: 6099-03-2
• Molecular Formula: C10H10O3
• Molecular Weight: 178.188
• Hs Code.: 29189900
• Wikidata: Q27165387
• Mol file: 6099-03-2.mol

Synonyms:2-Propenoic acid, 3-(methoxyphenyl)-;3-(2-Methoxy-phenyl)-acrylic acid;2-Methoxycinnamic acid;AI3-11206;3-(2-Methoxyphenyl)-2-propenoic acid;Spectrum_000358;SpecPlus_000703;Spectrum2_000453;Spectrum3_000257;Spectrum4_001552;SCHEMBL79060;KBioGR_002044;KBioSS_000838;DivK1c_006799;SPBio_000526;3-(methoxyphenyl)propenoic acid;KBio1_001743;KBio2_000838;KBio2_003406;KBio2_005974;KBio3_001174;3-(2-methoxyphenyl)-acrylic acid;AKOS017268919;FT-0633242;FT-0637132;FT-0697703;D85910;Q27165387

Chemical Property of 2-Propenoic acid, 3-(methoxyphenyl)-

Chemical Property:

• Appearance/Colour: light yellow crystalline powder
• Vapor Pressure: 9.64E-05mmHg at 25°C
• Melting Point: 182-186 °C
• Refractive Index: 1.5088 (estimate)
• Boiling Point: 325.1 °C at 760 mmHg
• PKA: pK1:4.462 (25°C)
• Flash Point: 130.3 °C
• PSA: 46.53000
• Density: 1.195 g/cm³
• LogP: 1.79300
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 178.062994177
• Heavy Atom Count: 13
• Complexity: 198

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxycinnamic acid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C=CC(=O)O

Technology Process of 2-Propenoic acid, 3-(methoxyphenyl)-

There total 15 articles about 2-Propenoic acid, 3-(methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 3-(2-methoxyphenyl)acrylate (33877-05-3) → 3-(2'-methoxyphenyl)propenoic acid (6099-03-2)

Guidance literature:

ethyl 3-(2-methoxyphenyl)acrylate; With sodium hydroxide; In ethanol;

With hydrogenchloride; In water;

DOI:10.1246/cl.130419

Reference yield: 98.0%

malonic acid (141-82-2) + ortho-anisaldehyde (135-02-4) → 3-(2'-methoxyphenyl)propenoic acid (6099-03-2)

Guidance literature:

With piperidine; In pyridine; at 85 ℃;

Reference yield: 94.0%

cycl-isopropylidene malonate (2033-24-1) + ortho-anisaldehyde (135-02-4) → 3-(2'-methoxyphenyl)propenoic acid (6099-03-2)

Guidance literature:

With 2-carbamoylhydrazine-1-sulfonic acid; In neat (no solvent); at 110 ℃; for 0.666667h; Reagent/catalyst; Green chemistry;

DOI:10.1039/c5ra14001c

upstream raw materials:

malonic acid

ortho-anisaldehyde

2-(2-methoxybenzylidene)malonic acid

water

Downstream raw materials:

2-hydroxycinnamic acid

N-(furan-2-ylmethyl)-3-(2-methoxyphenyl)acrylamide

3-(2-methoxyphenyl)-N-(pyridin-2-yl)acrylamide

C₁₃H₁₃NO₄

Refernces

• 1、 Malbari, Khushboo,Saha, Priyanka,Chawla-Sarkar, Mamta,Dutta, Shanta,Rai, Swita,Joshi, Mamata,Kanyalkar, Meena. "In quest of small-molecules as potent non-competitive inhibitors against influenza". . . Retrieved 2021/07/19.
• 2、 Gong, Zhaotang,Liu, Guoyun,Mu, Wenwen,Wang, Ziqing,Yang, Jie. "Meta-substituted piperlongumine derivatives attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis". . . Retrieved 2021/11/16.