Technology Process of Benzene, 1-methoxy-2-[(1E)-2-[4-(methoxymethoxy)phenyl]ethenyl]-
There total 3 articles about Benzene, 1-methoxy-2-[(1E)-2-[4-(methoxymethoxy)phenyl]ethenyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-methoxy-1-diethylphosphonomethyl-benzene;
With
18-crown-6 ether; sodium methylate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.0833333h;
4-methoxymethoxy-benzaldehyde;
With
18-crown-6 ether;
In
N,N-dimethyl-formamide;
at 20 - 120 ℃;
for 6h;
DOI:10.1021/jm049238e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 140 °C
2.1: NaOMe; 18/6-crown ether / dimethylformamide / 0.08 h / 20 °C
2.2: 90 percent / 18/6-crown ether / dimethylformamide / 6 h / 20 - 120 °C
With
18-crown-6 ether; sodium methylate;
In
N,N-dimethyl-formamide;
1.1: Arbuzov reaction / 2.2: Horner-Emmons-Wadsworth reaction;
DOI:10.1021/jm049238e
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NEt(i-Pr)2 / CH2Cl2 / 2 h / 25 °C
2.1: NaOMe; 18/6-crown ether / dimethylformamide / 0.08 h / 20 °C
2.2: 90 percent / 18/6-crown ether / dimethylformamide / 6 h / 20 - 120 °C
With
18-crown-6 ether; sodium methylate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
2.2: Horner-Emmons-Wadsworth reaction;
DOI:10.1021/jm049238e
