N 556

Base Information

• Chemical Name: N 556
• CAS No.: 110816-78-9
• Molecular Formula: C33H36 N2 O12 . 2 Cl H
• Molecular Weight: 725.571
• Mol file: 110816-78-9.mol

Synonyms:KY 556; N556

Chemical Property of N 556

Chemical Property:

• Vapor Pressure: 6.46E-25mmHg at 25°C
• Melting Point: 225-228 °C
• Boiling Point: 789.7°Cat760mmHg
• Flash Point: 212.5°C
• PSA: 209.82000
• Density: g/cm³
• LogP: 6.08330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N 556

There total 5 articles about N 556 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ 2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride (110816-78-9)

Guidance literature:

Reference yield:

2--1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane (110838-56-7) → 2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride (110816-78-9)

Guidance literature:

With hydrogenchloride; In chloroform; for 0.833333h;

DOI:10.1248/cpb.36.338

Reference yield:

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane (16150-45-1) → 2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride (110816-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 4.7 g / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / CH₂Cl₂ / 3 h

2: 16 g / 5N HCl-ethanol / CHCl₃ / 0.83 h

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;

DOI:10.1248/cpb.36.338

upstream raw materials:

2--1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane

Boc-Lys(Boc)-OH

disodium cromoglicate

Refernces

• 1、 -. "Therapeutic agent for allergic dermatitis". . . Retrieved 2008/06/13.
• 2、 -. "Cromoglycic acid derivatives, method of production thereof and pharmaceutical composition". . . Retrieved 2008/06/13.