Intal

Base Information

• Chemical Name: Intal
• CAS No.: 15826-37-6
• Molecular Formula: C23H14Na2O11
• Molecular Weight: 512.337
• Hs Code.: 29329990
• NSC Number: 756705,109500
• Mol file: 15826-37-6.mol

Synonyms:Aarane;Acid, Cromoglicic;Acid, Cromoglycic;Bicromat Spray;Cromoglicic Acid;Cromoglycate;Cromoglycate, Disodium;Cromoglycate, Sodium;Cromoglycic Acid;Cromolyn;Cromolyn Sodium;Disodium Cromoglycate;FPL 670;FPL-670;FPL670;Intal;Lomudal;Nalcrom;Nasalcrom;Opticrom;Sodium Cromoglycate;Vicrom

Chemical Property of Intal

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 241-242 °C
• Boiling Point: 752.3 °C at 760 mmHg
• Flash Point: 263.9 °C
• PSA: 179.37000
• LogP: -0.55490
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: Soluble in water, practically insoluble in ethanol (96 per cent).
• Water Solubility.: Soluble in water to 100mg/ml
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 8
• Exact Mass: 491.05903060
• Heavy Atom Count: 35
• Complexity: 835

Purity/Quality:

99%, ^*data from raw suppliers

CromolynDisodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)O)O)C(=O)C=C(O2)C(=O)O.[Na+]
• Description: Sodium cromoglycate is the sodium salt and common market from of cromoglicic acid, which is a synthetic compound, and as a mast cell stabilizer. It is capable of inhibiting the antigen-induced bronchospasms, and thus being used to treat the asthma and allergic rhinitis. It can also be applied as an ophthalmic solution for the treatment of conjunctivitis and systemic mastocytosis and ulcerative colitis. It is capable of inhibiting the degranulation of mast cells, further preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), the mediators of type I allergic reaction. It is also capable of inhibiting the release of inflammatory leukotrienes and inhibiting calcium influx.
• Uses: antiasthmatic, antiallergy Anti Asthamatic Chromone complex which blocks mast cell degranulation
• Indications: Cromolyn sodium (Intal) is chemically related drugs called chromones that is used for the prophylaxis of mild or moderate asthma. It is administered by inhalation and has very good safety profiles, making them particularly useful in treating children.
• Therapeutic Function: Bronchodilator
• Clinical Use: Cromolyn sodium is used almost exclusively for the prophylactic treatment of mild to moderate asthma and should not be used for the control of acute bronchospasm. This agent is effective in about 60 to 70% of children and adolescents with asthma. Unfortunately, there is no reliable means to predict which patients will respond.It is less effective in older patients and in patients with severe asthma. It may take up to 4 to 6 weeks of treatment for cromolyn sodium to be effective in chronic asthma, but it is effective after a single dose in exercise-induced asthma. With respect to clinical efficacy, cromolyn sodium and nedocromil sodium do not differ in a substantial way.

Technology Process of Intal

There total 13 articles about Intal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane (16150-45-1) → disodium cromoglicate (15826-37-6)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 65 ℃; for 5h; Temperature;

Reference yield: 91.0%

mannitol (69-65-8) → mannitol hexanitrate (15825-70-4)

Guidance literature:

With carbon dioxide; dinitrogen pentoxide; at 0 ℃; for 0.5h; under 45004.5 - 60006 Torr; Autoclave;

DOI:10.1016/j.mencom.2012.03.004

Reference yield:

mannitol (69-65-8) → O1,O2,O3,O5,O6-pentanitro-D-mannitol (30236-28-3) + mannitol hexanitrate (15825-70-4)

Guidance literature:

With sulfuric acid; nitric acid;

upstream raw materials:

2-hydroxypropyl methacrylate

EDMA

2,6-dihydroxylacetophenone

5-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester

Downstream raw materials:

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane

1,3-bis(2-methoxycarbonylchromon-5-yloxy)propan-2-ol

cromoglicinic acid

2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride

Refernces

• 1、 Kuchurov, Ilya V.,Fomenkov, Igor V.,Zlotin, Sergei G.,Tartakovsky, Vladimir A.. "Synthesis of nitric acid esters from alcohols in a dinitrogen pentoxide/carbon dioxide liquid system". experimental part. p. 67 - 69. Retrieved 2012/07/02.
• 2、 -. "Clear, stable cromolyn formulation". . . Retrieved 2008/06/13.