Hexanoic acid, 6-cyano-5-hydroxy-3-oxo-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Hexanoic acid, 6-cyano-5-hydroxy-3-oxo-, 1,1-dimethylethyl ester
• CAS No.: 848644-99-5
• Molecular Formula: C11H17NO4
• Molecular Weight: 227.26
• Mol file: 848644-99-5.mol

Synonyms:

Chemical Property of Hexanoic acid, 6-cyano-5-hydroxy-3-oxo-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Hexanoic acid, 6-cyano-5-hydroxy-3-oxo-, 1,1-dimethylethyl ester

There total 1 articles about Hexanoic acid, 6-cyano-5-hydroxy-3-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-cyano-3-hydroxybutyric acid, n-butyl ester → (5R)-1,1-dimethylethyl 6-cyano-5-hydroxy-3-oxo-hexanoate (848644-99-5) + 1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate (247592-53-6,196085-84-4)

Guidance literature:

With hydrogenchloride; lithium diisopropyl amide; In tetrahydrofuran; ethyl acetate;

Reference yield:

(5R)-1,1-dimethylethyl 6-cyano-5-hydroxy-3-oxo-hexanoate (848644-99-5) + diethyl methoxy borane (7397-46-8) → (3R,5R)-tert-butyl-6-cyano-3,5-dihydroxyhexanoate (125971-93-9) + 2-((4R, 6R)-6-cyanomethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid tert-butyl ester (125971-94-0,196085-84-4)

Guidance literature:

With sodium borohydrid; acetic acid; In tetrahydrofuran; methanol; water; ethyl acetate;

Downstream raw materials:

(3R,5R)-tert-butyl-6-cyano-3,5-dihydroxyhexanoate

2-((4R, 6R)-6-cyanomethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid tert-butyl ester

Refernces