1-Hydroxyethyl-4-nitropyrazole

Base Information

• Chemical Name: 1-Hydroxyethyl-4-nitropyrazole
• CAS No.: 42027-81-6
• Molecular Formula: C5H7N3O3
• Molecular Weight: 157.13
• Hs Code.: 2933199090
• Mol file: 42027-81-6.mol

Synonyms:2-(4-nitro-pyrazol-1-yl)-ethanol;1-(2-hydroxyethyl)-4-nitro-1H-pyrazole;N-(2-Hydroxyaethyl)-4-nitro-pyrazol;

Chemical Property of 1-Hydroxyethyl-4-nitropyrazole

Chemical Property:

• Vapor Pressure: 2.67E-05mmHg at 25°C
• Melting Point: 92-94oC
• Boiling Point: 343.5°C at 760 mmHg
• Flash Point: 161.6°C
• PSA: 83.87000
• Density: 1.53
• LogP: 0.30680
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Nitro-1H-pyrazol-1-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Hydroxyethyl-4-nitropyrazole

There total 4 articles about 1-Hydroxyethyl-4-nitropyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitro-1H-pyrazole (2075-46-9) + 2-bromoethanol (540-51-2) → 1-β-hysroxyethyl-4-nitropyrazole (42027-81-6)

Guidance literature:

With potassium carbonate; In ethyl bromide; acetonitrile; for 16h; Reflux;

Reference yield: 19.0%

2-[4-(4-amino-6-methylpyrimidin-2-yl)piperazin-1-yl]ethanol (1333960-64-7) + 6-chloro-4-[(2-methoxy-3-methylbenzoyl)amino]-N-methylpyridine-3-carboxamide → 1-β-hysroxyethyl-4-nitropyrazole (42027-81-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 6h;

Reference yield:

1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-1H-pyrazole (1346672-86-3) + 2-(1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-nitro-1H-pyrazol-5-yl)propan-2-ol → 2-(1-(2-hydroxyethyl)-4-nitro-1H-pyrazol-5-yl)propan-2-ol + 1-β-hysroxyethyl-4-nitropyrazole (42027-81-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;

upstream raw materials:

4-nitro-1H-pyrazole

2-bromoethanol

1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitro-1H-pyrazole

2-[4-(4-amino-6-methylpyrimidin-2-yl)piperazin-1-yl]ethanol

Downstream raw materials:

2-(4-amino-1H-pyrazol-1-yl)ethan-1-ol

N-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

2-(4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)ethyl methanesulfonate

2-(4-(5-(m-tolyl)oxazole-4-carboxamido)-1H-pyrazol-1-yl)ethyl 4-methyl-benzenesulfonate