5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-[[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]methyl]phenyl]-2,2-dimethyl-8-oxo-, 2-propenyl ester, (9S)-

Base Information

Chemical Name:5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-[[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]methyl]phenyl]-2,2-dimethyl-8-oxo-, 2-propenyl ester, (9S)-
CAS No.:848824-86-2
Molecular Formula:C34H61N3O7Si2
Molecular Weight:680.045
Hs Code.:

5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid,
9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-[[[(1,1-dimethylethyl)dimeth
ylsilyl]oxy]methyl]phenyl]-2,2-dimethyl-8-oxo-, 2-propenyl ester, (9S)-

Synonyms:

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Chemical Property of 5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-[[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]methyl]phenyl]-2,2-dimethyl-8-oxo-, 2-propenyl ester, (9S)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-[[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]methyl]phenyl]-2,2-dimethyl-8-oxo-, 2-propenyl ester, (9S)-

There total 4 articles about 5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-[[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]methyl]phenyl]-2,2-dimethyl-8-oxo-, 2-propenyl ester, (9S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 848824-85-1
{5-allyloxycarbonylamino-1-[4-(tert-butyl-dimethyl-silanyloxymethyl)phenylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

: 848824-86-2
{5-tert-butoxycarbonylamino-5-[[4-(tert-butyl-dimethyl-silanyloxymethyl)phenyl]-(2-trimethylsilanyl-ethoxymethyl)carbamoyl]-pentyl}-carbamic acid allyl ester

Guidance literature:: {5-allyloxycarbonylamino-1-[4-(tert-butyl-dimethyl-silanyloxymethyl)phenylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; for 0.166667h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; for 0.5h;
DOI:10.1021/jm040137q

Reference yield:

: 623-04-1
4-aminobenzenemethanol

: 848824-86-2
{5-tert-butoxycarbonylamino-5-[[4-(tert-butyl-dimethyl-silanyloxymethyl)phenyl]-(2-trimethylsilanyl-ethoxymethyl)carbamoyl]-pentyl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / EEDQ / CHCl₃ / 2 h / 20 °C

2.1: 87 percent / DIPEA / dimethylformamide / 0.17 h

3.1: NaH / tetrahydrofuran / 0.17 h

3.2: 78 percent / tetrahydrofuran / 0.5 h

With sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm040137q

Reference yield:

: 104669-73-0
N^α-(tert-butoxycarbonyl)-N^ε-(allyloxycarbonyl)-L-lysine

: 848824-86-2
{5-tert-butoxycarbonylamino-5-[[4-(tert-butyl-dimethyl-silanyloxymethyl)phenyl]-(2-trimethylsilanyl-ethoxymethyl)carbamoyl]-pentyl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / EEDQ / CHCl₃ / 2 h / 20 °C

2.1: 87 percent / DIPEA / dimethylformamide / 0.17 h

3.1: NaH / tetrahydrofuran / 0.17 h

3.2: 78 percent / tetrahydrofuran / 0.5 h

With sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm040137q