5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-(hydroxymethyl)phenyl]-2,2 -dimethyl-8-oxo-, 2-propenyl ester, (9S)-

Base Information

Chemical Name:5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-(hydroxymethyl)phenyl]-2,2 -dimethyl-8-oxo-, 2-propenyl ester, (9S)-
CAS No.:848824-87-3
Molecular Formula:C28H47N3O7Si
Molecular Weight:565.783
Hs Code.:

5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid,
9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-(hydroxymethyl)phenyl]-2,2
-dimethyl-8-oxo-, 2-propenyl ester, (9S)-

Synonyms:

Suppliers and Price of 5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-(hydroxymethyl)phenyl]-2,2 -dimethyl-8-oxo-, 2-propenyl ester, (9S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-(hydroxymethyl)phenyl]-2,2 -dimethyl-8-oxo-, 2-propenyl ester, (9S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-(hydroxymethyl)phenyl]-2,2 -dimethyl-8-oxo-, 2-propenyl ester, (9S)-

There total 5 articles about 5-Oxa-7,14-diaza-2-silapentadecan-15-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-7-[4-(hydroxymethyl)phenyl]-2,2 -dimethyl-8-oxo-, 2-propenyl ester, (9S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 848824-86-2
{5-tert-butoxycarbonylamino-5-[[4-(tert-butyl-dimethyl-silanyloxymethyl)phenyl]-(2-trimethylsilanyl-ethoxymethyl)carbamoyl]-pentyl}-carbamic acid allyl ester

: 848824-87-3
{5-tert-butoxycarbonylamino-5-[(4-hydroxymethylphenyl)-(2-trimethylsilanyl-ethoxymethyl)carbamoyl]pentyl}-carbamic acid allyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.25h;
DOI:10.1021/jm040137q

Reference yield:

: 623-04-1
4-aminobenzenemethanol

: 848824-87-3
{5-tert-butoxycarbonylamino-5-[(4-hydroxymethylphenyl)-(2-trimethylsilanyl-ethoxymethyl)carbamoyl]pentyl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 77 percent / EEDQ / CHCl₃ / 2 h / 20 °C

2.1: 87 percent / DIPEA / dimethylformamide / 0.17 h

3.1: NaH / tetrahydrofuran / 0.17 h

3.2: 78 percent / tetrahydrofuran / 0.5 h

4.1: 95 percent / TBAF / tetrahydrofuran / 0.25 h

With tetrabutyl ammonium fluoride; sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm040137q

Reference yield:

: 104669-73-0
N^α-(tert-butoxycarbonyl)-N^ε-(allyloxycarbonyl)-L-lysine

: 848824-87-3
{5-tert-butoxycarbonylamino-5-[(4-hydroxymethylphenyl)-(2-trimethylsilanyl-ethoxymethyl)carbamoyl]pentyl}-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 77 percent / EEDQ / CHCl₃ / 2 h / 20 °C

2.1: 87 percent / DIPEA / dimethylformamide / 0.17 h

3.1: NaH / tetrahydrofuran / 0.17 h

3.2: 78 percent / tetrahydrofuran / 0.5 h

4.1: 95 percent / TBAF / tetrahydrofuran / 0.25 h

With tetrabutyl ammonium fluoride; sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm040137q