4-CHLORO-1-METHYL-1H-QUINOLIN-2-ONE

Base Information

• Chemical Name: 4-CHLORO-1-METHYL-1H-QUINOLIN-2-ONE
• CAS No.: 32262-17-2
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.633
• Hs Code.: 2933790090
• Mol file: 32262-17-2.mol

Synonyms:Carbostyril,4-chloro-1-methyl- (4CI);4-Chloro-1-methylquinolin-2(1H)-one;NSC 39972;

Chemical Property of 4-CHLORO-1-METHYL-1H-QUINOLIN-2-ONE

Chemical Property:

• Vapor Pressure: 0.00554mmHg at 25°C
• Melting Point: 117-119 °C
• Refractive Index: 1.631
• Boiling Point: 274 °C at 760 mmHg
• PKA: -1.07±0.40(Predicted)
• Flash Point: 119.5 °C
• PSA: 22.00000
• Density: 1.33 g/cm³
• LogP: 2.19190

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-1-methylquinolin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-1-METHYL-1H-QUINOLIN-2-ONE

There total 3 articles about 4-CHLORO-1-METHYL-1H-QUINOLIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-1-methyl-2(1H)-quinolone (1677-46-9) → 4-chloro-1-methyl-1H-quinolin-2-one (32262-17-2) + 2,4-dichloroquinoline (703-61-7)

Guidance literature:

With trichlorophosphate; und anschliessend mit Phosphor(V)-chlorid;

DOI:10.1021/ja01213a041

Reference yield:

2,4-dichloroquinoline (703-61-7) → 4-chloro-1-methyl-1H-quinolin-2-one (32262-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 12 h / Reflux

1.2: 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 3 h / 0 - 20 °C

With hydrogenchloride; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm5005978

Reference yield:

4-hydroxy-1-methyl-2(1H)-quinolone (1677-46-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-chloro-1-methyl-1H-quinolin-2-one (32262-17-2) + 4-Chloro-3-formyl-1-methyl-2(1H)-quinolinone (96600-76-9)

Guidance literature:

With thionyl chloride; for 2h; Ambient temperature;

upstream raw materials:

4-hydroxy-1-methyl-2(1H)-quinolone

N,N-dimethyl-formamide

2,4-dichloroquinoline

Downstream raw materials:

4-hydrazino-1-methyl-2(1H)-quinolinone

1-methyl-4-phenyl-1H-quinolin-2-one

6-bromo-1-methyl-4-phenylquinolin-2(1H)-one

3-bromo-1-methyl-4-phenylquinolin-2(1H)-one