8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione

Base Information

Chemical Name:8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
CAS No.:90749-32-9
Molecular Formula:C29H36 N6 O2
Molecular Weight:500.644
Hs Code.:
Mol file:90749-32-9.mol

Synonyms:1H-Purine-2,6-dione,8-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]-3,7-dihydro-1-methyl-3-(2-methylpropyl)-(9CI); Laprafylline; S 9795

Suppliers and Price of 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
LAPRAFYLLINE 95.00%
5MG
$ 502.54

Total 0 raw suppliers

Chemical Property of 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione

Chemical Property:

Vapor Pressure:5.01E-19mmHg at 25°C
Boiling Point:692.5°Cat760mmHg
Flash Point:372.6°C
PSA：79.16000
Density:1.21g/cm³
LogP:2.90480

Purity/Quality:: LAPRAFYLLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione

There total 7 articles about 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 90749-63-6
1-methyl-3-isobutyl-8-(2-bromoethyl)xanthine

: 110469-11-9
3-Isobutyl-1-methyl-8-vinyl-3,7-dihydro-purine-2,6-dione

: 90749-32-9
1-methyl-3-isobutyl-8-[2-(4-diphenylmethyl-piperazinyl)ethyl]xanthine

Guidance literature:: With diphenylmethylpiperazine; In methanol; for 20h; Heating;
DOI:10.1016/0223-5234(87)90056-0

Reference yield:

: 110-85-0
piperazine

: 1-methyl-3-isobutyl-8-bromoethylxanthine

: 90749-32-9
1-methyl-3-isobutyl-8-[2-(4-diphenylmethyl-piperazinyl)ethyl]xanthine

Guidance literature:: With sodium hydrogencarbonate; In methanol; ethanol; ethyl acetate;

Reference yield:

: 54052-67-4
1-isobutyl-3-methyl-5-nitroso-6-amino uracil

: 90749-32-9
1-methyl-3-isobutyl-8-[2-(4-diphenylmethyl-piperazinyl)ethyl]xanthine

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / H₂ / Raney-NiW-2 / methanol / 4 h / 5320 Torr

2: 87 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h

3: 89 percent / 12N NaOH / H₂O / 2 h / 100 °C

4: 83 percent / 48percent HBr, HBr (gas) / 20 h / Heating

5: 72 percent / methanol / 20 h / Heating

With sodium hydroxide; hydrogen bromide; hydrogen; Raney-NiW-2; In methanol; water;
DOI:10.1016/0223-5234(87)90056-0