1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine

Base Information

Chemical Name:1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine
CAS No.:110480-50-7
Molecular Formula:C₃₂H₄₂N₆O₄
Molecular Weight:574.723
Hs Code.:

Synonyms:1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine

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Technology Process of 1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine

There total 6 articles about 1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 90749-32-9
1-methyl-3-isobutyl-8-[2-(4-diphenylmethyl-piperazinyl)ethyl]xanthine

: 96-24-2
3-monochloro-1,2-propanediol

: 110480-50-7
1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃;
DOI:10.1016/0223-5234(87)90056-0

Reference yield:

: 54052-67-4
1-isobutyl-3-methyl-5-nitroso-6-amino uracil

: 110480-50-7
1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / H₂ / Raney-NiW-2 / methanol / 4 h / 5320 Torr

2: 87 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h

3: 89 percent / 12N NaOH / H₂O / 2 h / 100 °C

4: 83 percent / 48percent HBr, HBr (gas) / 20 h / Heating

5: 72 percent / methanol / 20 h / Heating

6: 33 percent / K₂CO₃ / dimethylformamide / 110 °C

With sodium hydroxide; hydrogen bromide; hydrogen; potassium carbonate; Raney-NiW-2; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(87)90056-0

Reference yield:

: 78033-18-8
5,6-diamino-1-isobutyl-3-methyl-1H-pyrimidine-2,4-dione

: 110480-50-7
1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h

2: 89 percent / 12N NaOH / H₂O / 2 h / 100 °C

3: 83 percent / 48percent HBr, HBr (gas) / 20 h / Heating

4: 72 percent / methanol / 20 h / Heating

5: 33 percent / K₂CO₃ / dimethylformamide / 110 °C

With sodium hydroxide; hydrogen bromide; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(87)90056-0