Propanamide, N-[6-amino-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-3-methoxy-

Base Information

Chemical Name:Propanamide, N-[6-amino-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-3-methoxy-
CAS No.:90749-74-9
Molecular Formula:C₁₃H₂₂N₄O₄
Molecular Weight:298.342
Hs Code.:
Mol file:90749-74-9.mol

Synonyms:Propanamide, N-[6-amino-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-3-methoxy-

Suppliers and Price of Propanamide, N-[6-amino-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-3-methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanamide, N-[6-amino-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-3-methoxy-

Chemical Property:

PSA：108.35000
LogP:0.41440

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Propanamide, N-[6-amino-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-3-methoxy-

There total 2 articles about Propanamide, N-[6-amino-1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-5-pyrimidinyl]-3-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2544-06-1
3-Methoxypropionic acid

: 78033-18-8
5,6-diamino-1-isobutyl-3-methyl-1H-pyrimidine-2,4-dione

: 90749-74-9
1-isobutyl-3-methyl-5-(3-methoxypropionamido)-6-amino uracil

Guidance literature:: 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h;
DOI:10.1016/0223-5234(87)90056-0

Reference yield:

: 54052-67-4
1-isobutyl-3-methyl-5-nitroso-6-amino uracil

: 90749-74-9
1-isobutyl-3-methyl-5-(3-methoxypropionamido)-6-amino uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / H₂ / Raney-NiW-2 / methanol / 4 h / 5320 Torr

2: 87 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h

With hydrogen; Raney-NiW-2; In methanol;
DOI:10.1016/0223-5234(87)90056-0

Reference yield:

: 90749-74-9
1-isobutyl-3-methyl-5-(3-methoxypropionamido)-6-amino uracil

: 110480-50-7
1-methyl-3-isobutyl-7-(2,3-dihydroxypropyl)-8-[2-(4-diphenylmethylpiperazinyl)ethyl]xanthine

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / 12N NaOH / H₂O / 2 h / 100 °C

2: 83 percent / 48percent HBr, HBr (gas) / 20 h / Heating

3: 72 percent / methanol / 20 h / Heating

4: 33 percent / K₂CO₃ / dimethylformamide / 110 °C

With sodium hydroxide; hydrogen bromide; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(87)90056-0