Benzoic acid, 4-bromo-3-[[4-[1-cyclohexyl-3-[(1E)-3-ethoxy-2-methyl-3-oxo-1-propenyl ]-1H-pyrazol-5-yl]phenoxy]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Benzoic acid, 4-bromo-3-[[4-[1-cyclohexyl-3-[(1E)-3-ethoxy-2-methyl-3-oxo-1-propenyl ]-1H-pyrazol-5-yl]phenoxy]methyl]-, 1,1-dimethylethyl ester
CAS No.:849239-38-9
Molecular Formula:C33H39BrN2O5
Molecular Weight:623.587
Hs Code.:

Benzoic acid,
4-bromo-3-[[4-[1-cyclohexyl-3-[(1E)-3-ethoxy-2-methyl-3-oxo-1-propenyl
]-1H-pyrazol-5-yl]phenoxy]methyl]-, 1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of Benzoic acid, 4-bromo-3-[[4-[1-cyclohexyl-3-[(1E)-3-ethoxy-2-methyl-3-oxo-1-propenyl ]-1H-pyrazol-5-yl]phenoxy]methyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid, 4-bromo-3-[[4-[1-cyclohexyl-3-[(1E)-3-ethoxy-2-methyl-3-oxo-1-propenyl ]-1H-pyrazol-5-yl]phenoxy]methyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-bromo-3-[[4-[1-cyclohexyl-3-[(1E)-3-ethoxy-2-methyl-3-oxo-1-propenyl ]-1H-pyrazol-5-yl]phenoxy]methyl]-, 1,1-dimethylethyl ester

There total 10 articles about Benzoic acid, 4-bromo-3-[[4-[1-cyclohexyl-3-[(1E)-3-ethoxy-2-methyl-3-oxo-1-propenyl ]-1H-pyrazol-5-yl]phenoxy]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 503859-17-4
2-bromo-5-(tert-butoxycarbonyl)benzyl bromide

: 849239-32-3
ethyl (2E)-3-[1-cyclohexyl-5-(4-hydroxyphenyl)-1H-pyrazol-3-yl]-2-methyl-2-propenoate

: 849239-38-9
ethyl (2E)-3-(5-{4-[(t-butyl-2-bromo-5-phenylcarboxylate)methoxy]phenyl}-1-cyclohexyl-1H-pyrazol-3-yl)-2-methyl-2-propenoate

Guidance literature:: With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;

Reference yield:

: 347174-28-1
tert-butyl 4-bromo-3-methylbenzoate

: 849239-38-9
ethyl (2E)-3-(5-{4-[(t-butyl-2-bromo-5-phenylcarboxylate)methoxy]phenyl}-1-cyclohexyl-1H-pyrazol-3-yl)-2-methyl-2-propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 18.5 h / Inert atmosphere; Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); caesium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.086

Reference yield:

: 957794-57-9
C₁₉H₁₈O₅

: 849239-38-9
ethyl (2E)-3-(5-{4-[(t-butyl-2-bromo-5-phenylcarboxylate)methoxy]phenyl}-1-cyclohexyl-1H-pyrazol-3-yl)-2-methyl-2-propenoate

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3: manganese(IV) oxide / 1,2-dimethoxyethane / Reflux

4: n-butyllithium / tetrahydrofuran / 0 - 20 °C

5: boron trichloride / dichloromethane / -40 °C

6: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; boron trichloride; caesium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.086