Decanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-10-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-9-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, methyl ester, (2S,9S)-

Base Information

Chemical Name:Decanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-10-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-9-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, methyl ester, (2S,9S)-
CAS No.:849438-21-7
Molecular Formula:C₄₇H₆₀N₂O₇Si
Molecular Weight:793.088
Hs Code.:

Decanoic acid,
2-[[(1,1-dimethylethoxy)carbonyl]amino]-10-[[(1,1-dimethylethyl)dimethyl
silyl]oxy]-9-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, methyl ester,
(2S,9S)-

Synonyms:

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Chemical Property of Decanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-10-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-9-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, methyl ester, (2S,9S)-

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Technology Process of Decanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-10-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-9-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, methyl ester, (2S,9S)-

There total 21 articles about Decanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-10-[[(1,1-dimethylethyl)dimethyl silyl]oxy]-9-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, methyl ester, (2S,9S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 2-tert-butoxycarbonylamino-10-(tert-butyl-diphenyl-silanyloxy)-9-(9H-fluoren-9-ylmethoxycarbonylamino)-decanoic acid

: 849438-21-7
(2S,9S)-methyl 9-9H-fluoren-9-ylmethoxycarbonylamino-2-tert-butoxycarbonylamino-10-tert-butyldiphenylsilyloxydecanoate

Guidance literature:: With diazomethyl-trimethyl-silane; In methanol; toluene; at 20 ℃; for 1h;
DOI:10.3987/COM-04-S(P)40

Reference yield:

: 1155-62-0
N-benzyloxycarbonyl-L-glutamic acid

: 849438-21-7
(2S,9S)-methyl 9-9H-fluoren-9-ylmethoxycarbonylamino-2-tert-butoxycarbonylamino-10-tert-butyldiphenylsilyloxydecanoate

Guidance literature:: Multi-step reaction with 14 steps

1.1: 98 percent / BF_3.etherate

2.1: 79 percent / LiBH₄ / tetrahydrofuran; methanol / 4 h / 0 °C

3.1: 88 percent / p-TsOH / CH₂Cl₂ / 24 h / 20 °C

4.1: triethylamine / CH₂Cl₂ / 0.5 h / -20 °C

5.1: tetrahydrofuran / 1 h

6.1: magnesium monoperoxy phthalate / tetrahydrofuran; ethanol

7.1: CeCl₃*7H₂O; oxalic acid / acetonitrile / 20 °C

8.1: 38.6 g / imidazole / dimethylformamide / 2 h / 20 °C

9.1: N-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C

9.2: 85 percent / tetrahydrofuran / 1.5 h / -78 °C

10.1: 72 percent / Na₂HPO₄; sodium amalgam / methanol / 3.33 h / 0 - 20 °C

11.1: H₂; Pd(OH)2 on charcoal / ethyl acetate / 24 h / 20 °C

12.1: 5.44 g / Na₂CO₃ / tetrahydrofuran; H₂O / 1 h / 20 °C

13.1: Jones' reagent / acetone / 6 h / 0 °C

14.1: 3.42 g / (trimethylsilyl)diazomethane / methanol; toluene / 1 h / 20 °C

With 1H-imidazole; disodium hydrogenphosphate; sodium amalgam; lithium borohydride; n-butyllithium; jones' reagent; cerium(III) chloride; palladium hydroxide - carbon; boron trifluoride diethyl etherate; hydrogen; oxalic acid; sodium carbonate; toluene-4-sulfonic acid; magnesium monoperoxyphthalate hexahydrate; triethylamine; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.3987/COM-04-S(P)40

Reference yield:

: 67436-17-3
dimethyl (S)-N-(benzyloxycarbonyl)glutamate

: 849438-21-7
(2S,9S)-methyl 9-9H-fluoren-9-ylmethoxycarbonylamino-2-tert-butoxycarbonylamino-10-tert-butyldiphenylsilyloxydecanoate

Guidance literature:: Multi-step reaction with 13 steps

1.1: 79 percent / LiBH₄ / tetrahydrofuran; methanol / 4 h / 0 °C

2.1: 88 percent / p-TsOH / CH₂Cl₂ / 24 h / 20 °C

3.1: triethylamine / CH₂Cl₂ / 0.5 h / -20 °C

4.1: tetrahydrofuran / 1 h

5.1: magnesium monoperoxy phthalate / tetrahydrofuran; ethanol

6.1: CeCl₃*7H₂O; oxalic acid / acetonitrile / 20 °C

7.1: 38.6 g / imidazole / dimethylformamide / 2 h / 20 °C

8.1: N-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C

8.2: 85 percent / tetrahydrofuran / 1.5 h / -78 °C

9.1: 72 percent / Na₂HPO₄; sodium amalgam / methanol / 3.33 h / 0 - 20 °C

10.1: H₂; Pd(OH)2 on charcoal / ethyl acetate / 24 h / 20 °C

11.1: 5.44 g / Na₂CO₃ / tetrahydrofuran; H₂O / 1 h / 20 °C

12.1: Jones' reagent / acetone / 6 h / 0 °C

13.1: 3.42 g / (trimethylsilyl)diazomethane / methanol; toluene / 1 h / 20 °C

With 1H-imidazole; disodium hydrogenphosphate; sodium amalgam; lithium borohydride; n-butyllithium; jones' reagent; cerium(III) chloride; palladium hydroxide - carbon; hydrogen; oxalic acid; sodium carbonate; toluene-4-sulfonic acid; magnesium monoperoxyphthalate hexahydrate; triethylamine; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.3987/COM-04-S(P)40