8-Fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one

Base Information

Chemical Name:8-Fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one
CAS No.:68351-37-1
Molecular Formula:C16H13F2NO
Molecular Weight:273.282
Hs Code.:
DSSTox Substance ID:DTXSID10987898

Synonyms:BRN 1487784;VUFB-10132;8-Fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one;1,3,4,5-Tetrahydro-8-fluoro-5-(4-fluorophenyl)-2H-1-benzazepin-2-one;2H-1-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-fluoro-5-(4-fluorophenyl)-;5-21-09-00089 (Beilstein Handbook Reference);68351-37-1;C16H13F2NO;SCHEMBL4871374;DTXSID10987898;C16-H13-F2-N-O;LS-28034;8-Fluoro-5-(4-fluorophenyl)-4,5-dihydro-3H-1-benzazepin-2-ol

Suppliers and Price of 8-Fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one

Chemical Property:

Vapor Pressure:2.33E-06mmHg at 25°C
Boiling Point:392.2°Cat760mmHg
Flash Point:191°C
Density:1.247g/cm³
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:273.09652036
Heavy Atom Count:20
Complexity:354

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC2=C(C1C3=CC=C(C=C3)F)C=CC(=C2)F

Technology Process of 8-Fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one

There total 7 articles about 8-Fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 68351-22-4
7-fluoro-4-(4-fluorophenyl)-1-tetralone oxime

: 68351-37-1
8-fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one

: 77795-89-2
7-fluoro-4-(4-fluorophenyl)-1-naphthylamine

Guidance literature:: With PPA; at 130 ℃;
DOI:10.1135/cccc19810148

Reference yield:

: 68351-22-4
7-fluoro-4-(4-fluorophenyl)-1-tetralone oxime

: 68351-37-1
8-fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one

Guidance literature:: With phosphoric acid; phosphorus pentoxide; In water; at 130 ℃; for 0.0833333h;

Reference yield:

: 462-06-6
fluorobenzene

: 68351-37-1
8-fluoro-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: trifluorormethanesulfonic acid / 1 h / 75 °C

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / Heating / reflux

3: phosphoric acid; phosphorus pentoxide / water / 0.08 h / 130 °C

With trifluorormethanesulfonic acid; phosphoric acid; hydroxylamine hydrochloride; phosphorus pentoxide; sodium hydrogencarbonate; In methanol; water;