Technology Process of Acetamide,
2,2,2-trichloro-N-[(1S,2E)-1-(pentafluorophenyl)-2,5-hexadienyl]-
There total 3 articles about Acetamide,
2,2,2-trichloro-N-[(1S,2E)-1-(pentafluorophenyl)-2,5-hexadienyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1E,3S)-1-pentafluorophenylhexa-1,5-dien-3-ol;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -42 ℃;
for 0.5h;
trichloroacetonitrile;
In
tetrahydrofuran;
at -42 - 20 ℃;
for 1h;
With
potassium carbonate;
In
xylene;
at 150 ℃;
for 14h;
DOI:10.1021/jo048144+
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 93 percent / toluene / 1 h / 80 °C
2.1: diethyl ether; pentane / 3 h / -100 - -78 °C
2.2: aq. NaOH; aq. H2O2 / diethyl ether; pentane / 14 h / -78 - 20 °C
3.1: NaN(SiMe3)2 / tetrahydrofuran / 0.5 h / -42 °C
3.2: tetrahydrofuran / 1 h / -42 - 20 °C
3.3: 74 percent / K2CO3 / xylene / 14 h / 150 °C
With
sodium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; toluene; pentane;
1.1: Wittig-Horner olefination / 3.3: Overman rearrangement;
DOI:10.1021/jo048144+
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethyl ether; pentane / 3 h / -100 - -78 °C
1.2: aq. NaOH; aq. H2O2 / diethyl ether; pentane / 14 h / -78 - 20 °C
2.1: NaN(SiMe3)2 / tetrahydrofuran / 0.5 h / -42 °C
2.2: tetrahydrofuran / 1 h / -42 - 20 °C
2.3: 74 percent / K2CO3 / xylene / 14 h / 150 °C
With
sodium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; pentane;
2.3: Overman rearrangement;
DOI:10.1021/jo048144+
