2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-1-(4-fluorophenyl)-, (3R,4S)-

Base Information

Chemical Name:2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-1-(4-fluorophenyl)-, (3R,4S)-
CAS No.:849799-39-9
Molecular Formula:C36H49F2NO3Si2
Molecular Weight:637.958
Hs Code.:

2-Azetidinone,
3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]-
4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-1-(4-fluorophenyl)-,
(3R,4S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-1-(4-fluorophenyl)-, (3R,4S)-

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Technology Process of 2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-1-(4-fluorophenyl)-, (3R,4S)-

There total 1 articles about 2-Azetidinone, 3-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-(4-fluorophenyl)propyl]- 4-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-1-(4-fluorophenyl)-, (3R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 163222-33-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
ezetemibe

: 849799-39-9
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-fluoro-phenyl)-azetidin-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 5h;
DOI:10.1021/ol0502127 DOI:10.1021/jm050422p

Reference yield: 79.0%

: 849799-39-9
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-fluoro-phenyl)-azetidin-2-one

: 866918-08-3
5-(tert-butyl-dimethyl-silanyloxy)-2-[[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-(4-fluoro-phenylamino)-methyl]-5-(4-fluoro-phenyl)-pentan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 23h;
DOI:10.1021/jm050422p

Reference yield: 63.0%

: 849799-39-9
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-fluoro-phenyl)-azetidin-2-one

: 849799-40-2
3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-6-fluoro-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In diethyl ether; for 0.666667h; Heating / reflux;

3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(4-fluoro-phenyl)-azetidin-2-one; In diethyl ether; at 0 ℃; for 0.5h;