Bicyclo[2.2.1]heptane-2-carboxylic acid

Base Information

• Chemical Name: Bicyclo[2.2.1]heptane-2-carboxylic acid
• CAS No.: 824-62-4
• Molecular Formula: C₈H₁₂O₂
• Molecular Weight: 140.182
• Hs Code.: 2916209090
• European Community (EC) Number: 212-532-2,621-576-5,878-973-3
• NSC Number: 152331
• DSSTox Substance ID: DTXSID90901315
• Nikkaji Number: J195.079G
• Wikidata: Q72496718
• Mol file: 824-62-4.mol

Synonyms:bicyclo[2.2.1]heptane-2-carboxylic acid;824-62-4;2-Norbornanecarboxylic acid;Norbornane-2-carboxylic acid;Bicyclo(2.2.1)heptane-2-carboxylic acid;2-Norbornanecarboxylic acid, endo-;(2S)-Norbornane-2-carboxylicacid;EINECS 212-532-2;Bicyclo(2.2.1)heptane-2-carboxylic acid, endo-;Bicyclo[2.2.1]heptane-2-carboxylic acid, endo-;exo-Norbornane-2-carboxylic acid;934-29-2;endo-Bicyclo(2.2.1)heptane-2-carboxylic acid;Bicyclo[2.2.1]heptane-2-carboxylicacid;NoName_413;2-norbornanecarboxlic acid;(1R,2R,4S)-bicyclo[2.2.1]heptane-2-carboxylic acid;2-Norcamphanecarboxylic acid;2-norbornane carboxylic acid;NCIOpen2_001057;SCHEMBL108141;DTXSID90901315;STR06793;NSC152331;STK430693;AKOS001175785;AKOS016874856;AB86072;AB86124;AB86378;CS-W016458;NSC 152331;NSC-152331;PB48233;PS-4221;AM807074;Bicyclo[2.2.1]heptane-2-carboxylic aci;LS-97094;Bicyclo(2,2,1)heptane-2-carboxylic acid;FT-0622956;EN300-15401;A849093;ENDO-BICYCLO(2.2.1)HEPTANE-2-CARBOXYLIC A CID;Z147433488;Bicyclo[2.2.1]heptane-2-carboxylic acid

Chemical Property of Bicyclo[2.2.1]heptane-2-carboxylic acid

Chemical Property:

• Appearance/Colour: White crystal with special odor
• Vapor Pressure: 0.008mmHg at 25°C
• Melting Point: 40°C
• Refractive Index: 1.4855
• Boiling Point: 247.8 °C at 760 mmHg
• PKA: 4.83±0.20(Predicted)
• Flash Point: 113.8 °C
• PSA: 37.30000
• Density: 1.193 g/cm³
• LogP: 1.50720
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water.
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 140.083729621
• Heavy Atom Count: 10
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

Bicyclo[2.2.1]heptane-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2CC1CC2C(=O)O
• Uses: Norbornane-2-carboxylic acid is used in the preparation of 2-Bromonorbornane-1-carboxylic acid. It is also used as Pharmaceutical intermediates.

Technology Process of Bicyclo[2.2.1]heptane-2-carboxylic acid

There total 16 articles about Bicyclo[2.2.1]heptane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

palladium-carbon + 5-norbornene-endo-2-carboxylic acid (934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7,120-74-1) → norbornane-2-carboxylic acid (934-28-1,934-29-2,2566-58-7,2566-59-8,61967-05-3,79026-23-6,117894-69-6,130793-99-6,824-62-4)

Guidance literature:

Reference yield: 99.0%

5-norbornene-endo-2-carboxylic acid (934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7,120-74-1) → norbornane-2-carboxylic acid (934-28-1,934-29-2,2566-58-7,2566-59-8,61967-05-3,79026-23-6,117894-69-6,130793-99-6,824-62-4)

Guidance literature:

With palladium diacetate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In dichloromethane; at 25 ℃; for 12h; Schlenk technique; Inert atmosphere;

Reference yield: 95.0%

→ norbornane-2-carboxylic acid (934-28-1,934-29-2,2566-58-7,2566-59-8,61967-05-3,79026-23-6,117894-69-6,130793-99-6,824-62-4)

Guidance literature:

upstream raw materials:

5-norbornene-endo-2-carboxylic acid

norborn-2-ene

carbon dioxide

2-norbornanecarbonitrile

Downstream raw materials:

bicyclo[2.2.1]heptane-2-carboxamide

Bicyclo[2.2.1]heptane-2-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

C₂₁H₂₁NO₂

exo-2-bromobicyclo<2.2.1>heptane-1-carboxylic acid