1-Piperidinecarboxylic acid, 2-(hydroxymethyl)-3-(phenylmethoxy)-, 1,1-dimethylethyl ester, (2S,3R)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 2-(hydroxymethyl)-3-(phenylmethoxy)-, 1,1-dimethylethyl ester, (2S,3R)-
CAS No.:849928-64-9
Molecular Formula:C18H27NO4
Molecular Weight:321.417
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperidinecarboxylic acid, 2-(hydroxymethyl)-3-(phenylmethoxy)-, 1,1-dimethylethyl ester, (2S,3R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 2-(hydroxymethyl)-3-(phenylmethoxy)-, 1,1-dimethylethyl ester, (2S,3R)-

There total 18 articles about 1-Piperidinecarboxylic acid, 2-(hydroxymethyl)-3-(phenylmethoxy)-, 1,1-dimethylethyl ester, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (1S,2R,6R)-2-benzyloxy-8-tert-butyloxycarbonyl-6-oxa-8-azabicyclo[3.2.1]octane

: 849928-64-9
tert-butyl (2S,3R)-3-(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo902324h

Reference yield:

: (2R,3R)-2,3-epoxy-4-pentenyl-N-allylcarbamate

: 849928-64-9
tert-butyl (2S,3R)-3-(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: NaN(TNS)2 / tetrahydrofuran / 23 °C

2: Grubbs's catalyst / CH₂Cl₂

3: 99 percent / H₂ / Pd/C / ethyl acetate / 1 h / 23 °C / 760 Torr

4: 97 percent / NaH / dimethylformamide / -20 - 23 °C

5: aq. NaOH / methanol; H₂O / 14 h / 100 °C

6: 0.082 g / aq. NaHCO₃ / ethyl acetate / 14 h / 23 °C

With sodium hydroxide; hydrogen; sodium hexamethyldisilazane; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo048172s

Reference yield:

: 448896-88-6
(8R,8aS)-8-hydroxy-8,8a-dihydro-1H-oxazolo[3,4-a]pyridin-3(5H)-one

: 849928-64-9
tert-butyl (2S,3R)-3-(benzyloxy)-2-(hydroxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd/C / ethyl acetate / 1 h / 23 °C / 760 Torr

2: 97 percent / NaH / dimethylformamide / -20 - 23 °C

3: aq. NaOH / methanol; H₂O / 14 h / 100 °C

4: 0.082 g / aq. NaHCO₃ / ethyl acetate / 14 h / 23 °C

With sodium hydroxide; hydrogen; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo048172s