3-Pyrrolidinecarboxylic acid, 4-hydroxy-1-(phenylmethyl)-, ethyl ester, (3S,4R)-

Base Information

Chemical Name:3-Pyrrolidinecarboxylic acid, 4-hydroxy-1-(phenylmethyl)-, ethyl ester, (3S,4R)-
CAS No.:849935-77-9
Molecular Formula:C14H19NO3
Molecular Weight:249.31
Hs Code.:

Synonyms:(3S,4R)-1-N-benzyl-4-hydroxypyrrolidine-3-carboxylic acid ethyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Pyrrolidinecarboxylic acid, 4-hydroxy-1-(phenylmethyl)-, ethyl ester, (3S,4R)-

Chemical Property:

Melting Point:51-52 °C
Boiling Point:364.2±42.0 °C(Predicted)
PSA：49.77000
Density:1.191±0.06 g/cm3(Predicted)
LogP:0.98030

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyrrolidinecarboxylic acid, 4-hydroxy-1-(phenylmethyl)-, ethyl ester, (3S,4R)-

There total 5 articles about 3-Pyrrolidinecarboxylic acid, 4-hydroxy-1-(phenylmethyl)-, ethyl ester, (3S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 795-18-6
3-(benzyl-ethoxy-carbonylmethyl-amino)-propionic acid ethyl ester

: 849935-77-9
ethyl (3S,4R)-1-benzyl-4-hydroxypyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium tetrachloride / dichloromethane / 0.5 h / -10 °C

1.2: 2.5 h / -10 °C

2.1: methanol; sodium tetrahydroborate / 0 - 20 °C

3.1: lipase from Candida antarctica / tert-butyl methyl ether / 2.5 h / 40 °C / Enzymatic reaction

With methanol; sodium tetrahydroborate; lipase from Candida antarctica; titanium tetrachloride; In dichloromethane; tert-butyl methyl ether; 1.1: |Dieckmann Condensation / 1.2: |Dieckmann Condensation;
DOI:10.1016/j.bmc.2020.115507

Reference yield:

: 1027-35-6
1-Benzyl-4-oxo-pyrrolidine-3-carboxylic Acid Ethyl Ester

: 849935-77-9
ethyl (3S,4R)-1-benzyl-4-hydroxypyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate / 0 - 20 °C

2: lipase from Candida antarctica / tert-butyl methyl ether / 2.5 h / 40 °C / Enzymatic reaction

With methanol; sodium tetrahydroborate; lipase from Candida antarctica; In tert-butyl methyl ether;
DOI:10.1016/j.bmc.2020.115507

Reference yield:

: 3783-61-7
diethyl 2-azabutane-1,4-dicarboxylate

: 849935-77-9
ethyl (3S,4R)-1-benzyl-4-hydroxypyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / acetonitrile / 16 h / Inert atmosphere

2.1: titanium tetrachloride / dichloromethane / 0.5 h / -10 °C

2.2: 2.5 h / -10 °C

3.1: methanol; sodium tetrahydroborate / 0 - 20 °C

4.1: lipase from Candida antarctica / tert-butyl methyl ether / 2.5 h / 40 °C / Enzymatic reaction

With methanol; sodium tetrahydroborate; lipase from Candida antarctica; titanium tetrachloride; sodium hydrogencarbonate; In dichloromethane; tert-butyl methyl ether; acetonitrile; 2.1: |Dieckmann Condensation / 2.2: |Dieckmann Condensation;
DOI:10.1016/j.bmc.2020.115507