1027-35-6

Basic information

• Product Name: ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate
• Synonyms: ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate;1-(benzyl)-4-keto-pyrrolidine-3-carboxylic acid ethyl ester;ethyl 4-oxo-1-(phenylmethyl)pyrrolidine-3-carboxylate;1-Benzyl-4-oxo-pyrrolidine-3-carboxylic acid ethyl ester;Ethyl 1-benzyl-4-pyrrolidone-3-carboxylate;ethyl-benzyl-4-oxopyrrolidine-3-carboxylate;3-Pyrrolidinecarboxylicacid, 4-oxo-1-(phenylMethyl)-, ethyl ester;4-oxo-1-(phenylmethyl)-3-Pyrrolidinecarboxylic acid ethyl ester
• CAS NO: 1027-35-6
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.289680
• Mol File: 1027-35-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 358.1 °C at 760 mmHg
• Flash Point: 170.4 °C
• Appearance: /
• Density: 1.184
• Vapor Pressure: 2.6E-05mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 10.88±0.20(Predicted)
• CAS DataBase Reference: ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate(1027-35-6)
• EPA Substance Registry System: ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate(1027-35-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1027-35-6(Hazardous Substances Data)

Usage

General Description

Ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate is a chemical compound with the molecular formula C16H19NO3. It is commonly used in the synthesis and production of pharmaceuticals and organic compounds. This chemical is a derivative of pyrrolidine and is often employed as a building block in drug discovery and development. It possesses potential pharmacological properties and has been studied for its potential therapeutic uses, particularly in the treatment of various medical conditions. Ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate is a versatile compound with a wide range of applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C14H17NO3/c1-2-18-14(17)12-9-15(10-13(12)16)8-11-6-4-3-5-7-11/h3-7,12H,2,8-10H2,1H3

Upstream product

• 23583-21-3 ethyl-3-benzylamino propionate 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 
• 140-88-5 ethyl acrylate 
• 795-18-6 3-(benzyl-ethoxy-carbonylmethyl-amino)-propionic acid ethyl ester 

Downstream Products

• 779323-58-9 6-benzyl-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin 
• 785775-01-1 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine 
• 903129-71-5 tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate 
• 128740-14-7 (R,R)-8-benzyl-2,8-diazabicyclo[4.3.0]-nonane 
• 635698-34-9 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione 
• 10280-53-2 6-benzyl-2-isopropyl-3,5,6,7-tetrahydro-pyrrolo[3,4-d]pyrimidin-4-one 
• 154472-50-1 1-benzyl-3-carboethoxy-4-benzylaminopyrrolidine 
• 780-15-4 1-benzyl-3-hydroxymethyl-4-hydroxypyrrolidine 

Relevant articles and documents

Regioselective titanium tetrachloride mediated five membered hetero-cyclisations

Highly regioselective titanium IV mediated, Dieckmann type cyclisation in the synthesis of 5-membered nitrogen and sulfur heterocycles is described.

Pyrrolidine [3,4-d] pyrimidine derivatives, preparation method and its application

The invention discloses a pyrrolidine[3,4-d]pyrimidine derivative and a preparation method and an application thereof. The pyrrolidine[3,4-d]pyrimidine derivative is an inhibitor of a type I insulin-like growth factor receptor (IGF-1R), and has a good IGF-1R inhibiting function and a good cancer cell proliferation inhibiting function, so that the pyrrolidine[3,4-d]pyrimidine derivative can be taken as a therapeutic agent for treating tumors and relevant diseases.

6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives

The present invention concerns compounds of the formula: STR1 wherein R is a lower alkyl group, an aryl group or an alkylaryl group and X and Y are the same or different, and each is OH, NH2, or SH. The aryl group or the aryl moiety of the alkylaryl group may be unsubstituted, monosubstituted, disubstituted or trisubstituted. If substituted, each substituent may independently be an alkyl group, an alkyloxy group or a halogen. The present invention also provides methods for synthesizing the compounds described above.