2-Fluoro-N,N-dimethylpyridin-4-amine

Base Information

• Chemical Name: 2-Fluoro-N,N-dimethylpyridin-4-amine
• CAS No.: 849937-80-0
• Molecular Formula: C₇H₉FN₂
• Molecular Weight: 140.16
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID30479220
• Wikidata: Q82313194
• Mol file: 849937-80-0.mol

Synonyms:2-Fluoro-N,N-dimethylpyridin-4-amine;849937-80-0;(2-FLUORO-PYRIDIN-4-YL)-DIMETHYL-AMINE;SCHEMBL21849250;DTXSID30479220;ZIB93780;MFCD09031022;2-Fluoro-N,N-dimethyl-4-pyridinamine;AKOS006289585;DS-7292;SB75420;CS-0151325;2-Fluoro-N pound notN-dimethylpyridin-4-amine;Y10856;A863833;F1908-2680

Chemical Property of 2-Fluoro-N,N-dimethylpyridin-4-amine

Chemical Property:

• PSA: 16.13000
• LogP: 1.28670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 140.07497646
• Heavy Atom Count: 10
• Complexity: 106

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-N,N-dimethylpyridin-4-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC(=NC=C1)F
• Uses: 2-Fluoro-N,N-dimethyl-4-pyridinamine is a useful building block for elaborate fluorinated organic compounds.

Technology Process of 2-Fluoro-N,N-dimethylpyridin-4-amine

There total 5 articles about 2-Fluoro-N,N-dimethylpyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,4-difluoropyridine (34941-90-7) + dimethyl amine (124-40-3) → 2-fluoro-N,N-dimethylpyridin-4-amine (849937-80-0)

Guidance literature:

In water; at 25 ℃; for 2h;

DOI:10.1021/jo047962z

Reference yield:

2,4,6-trifluoro-3-(triethylsilyl)pyridine (837364-95-1) → 2-fluoro-N,N-dimethylpyridin-4-amine (849937-80-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / H₂NNH₂*H₂O / tetrahydrofuran / 2 h / 50 °C

2: 85 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C

3: 51 percent / CuSO₄*5H₂O / H₂O / 0.42 h / Heating

4: 94 percent / H₂O / 2 h / 25 °C

With tetrabutyl ammonium fluoride; hydrazine hydrate; copper(II) sulfate; In tetrahydrofuran; water;

DOI:10.1021/jo047962z

Reference yield:

2,4-difluoro-6-hydrazino-3-(triethylsilyl)pyridine (837364-96-2) → 2-fluoro-N,N-dimethylpyridin-4-amine (849937-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C

2: 51 percent / CuSO₄*5H₂O / H₂O / 0.42 h / Heating

3: 94 percent / H₂O / 2 h / 25 °C

With tetrabutyl ammonium fluoride; copper(II) sulfate; In tetrahydrofuran; water;

DOI:10.1021/jo047962z

upstream raw materials:

2,4-difluoropyridine

dimethyl amine

2,4,6-trifluoro-3-(triethylsilyl)pyridine

2,4-difluoro-6-hydrazino-3-(triethylsilyl)pyridine