4-(2-aminoethyl)phenyl acetate hydrochloride (1:1)

Base Information

• Chemical Name: 4-(2-aminoethyl)phenyl acetate hydrochloride (1:1)
• CAS No.: 14383-55-2
• Molecular Formula: C10H13 N O2 . Cl H
• Molecular Weight: 215.68
• Mol file: 14383-55-2.mol

Synonyms:Phenol,4-(2-aminoethyl)-, acetate (ester), hydrochloride (9CI); Phenol,p-(2-aminoethyl)-, acetate (ester), hydrochloride (8CI); Tyramine, acetate,hydrochloride (6CI); O-Acetyltyramine hydrochloride; O4-Acetyltyraminehydrochloride; b-(4-Acetoxyphenyl)ethylaminehydrochloride

Chemical Property of 4-(2-aminoethyl)phenyl acetate hydrochloride (1:1)

Chemical Property:

• Vapor Pressure: 0.0024mmHg at 25°C
• Boiling Point: 288°Cat760mmHg
• Flash Point: 145.8°C
• PSA: 52.32000
• Density: g/cm³
• LogP: 2.61540

Purity/Quality:

99% ^*data from raw suppliers

PHENOL, P-(2-AMINOETHYL)-, ACETATE (ESTER), HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-aminoethyl)phenyl acetate hydrochloride (1:1)

There total 4 articles about 4-(2-aminoethyl)phenyl acetate hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-(2-Nitrovinyl)benzoic acid methyl ester (22568-50-9) → 4-(2-Aminoethyl)benzoic acid methyl ester hydrochloride (14383-55-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 3h;

DOI:10.1080/00304940009355938

Reference yield:

4-formylphenyl acetate (878-00-2) → 4-(2-Aminoethyl)benzoic acid methyl ester hydrochloride (14383-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 24 h / 25 °C

2: DMAP; Ac₂O / diethyl ether / 25 °C

3: 76 percent / H₂; aq. HCl / 5 percent Pd/C / methanol / 3 h

With hydrogenchloride; dmap; potassium tert-butylate; hydrogen; acetic anhydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; tert-butyl alcohol; 1: Addition / 2: Elimination / 3: Catalytic hydrogenation;

DOI:10.1080/00304940009355938

Reference yield:

4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester (23860-19-7) → 4-(2-Aminoethyl)benzoic acid methyl ester hydrochloride (14383-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP; Ac₂O / diethyl ether / 25 °C

2: 76 percent / H₂; aq. HCl / 5 percent Pd/C / methanol / 3 h

With hydrogenchloride; dmap; hydrogen; acetic anhydride; palladium on activated charcoal; In methanol; diethyl ether; 1: Elimination / 2: Catalytic hydrogenation;

DOI:10.1080/00304940009355938

upstream raw materials:

4-(2-Nitrovinyl)benzoic acid methyl ester

4-formylphenyl acetate

4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester