4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester

Base Information

• Chemical Name: 4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester
• CAS No.: 23860-19-7
• Molecular Formula: C₁₀H₁₁NO₅
• Molecular Weight: 225.201
• Mol file: 23860-19-7.mol

Synonyms:4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester

Chemical Property of 4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester

There total 1 articles about 4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-formylphenyl acetate (878-00-2) + nitromethane (75-52-5) → 4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester (23860-19-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at 25 ℃; for 24h;

DOI:10.1080/00304940009355938

Reference yield:

4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester (23860-19-7) → 4-(2-Aminoethyl)benzoic acid methyl ester hydrochloride (14383-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP; Ac₂O / diethyl ether / 25 °C

2: 76 percent / H₂; aq. HCl / 5 percent Pd/C / methanol / 3 h

With hydrogenchloride; dmap; hydrogen; acetic anhydride; palladium on activated charcoal; In methanol; diethyl ether; 1: Elimination / 2: Catalytic hydrogenation;

DOI:10.1080/00304940009355938

Reference yield:

4-(1-Hydroxy-2-nitroethyl)benzoic acid methyl ester (23860-19-7) → 4-(2-Nitrovinyl)benzoic acid methyl ester (22568-50-9)

Guidance literature:

With dmap; acetic anhydride; In diethyl ether; at 25 ℃;

DOI:10.1080/00304940009355938

upstream raw materials:

4-formylphenyl acetate

nitromethane

Downstream raw materials:

4-(2-Nitrovinyl)benzoic acid methyl ester

4-(2-Aminoethyl)benzoic acid methyl ester hydrochloride