HO-PEG5-tBu

Base Information

Chemical Name:HO-PEG5-tBu
CAS No.:850090-09-4
Molecular Formula:C17H34O8
Molecular Weight:366.452
Hs Code.:2918999090
Mol file:850090-09-4.mol

Synonyms:18-hydroxy-4,7,10,13,16-pentaoxaoctadecanoic acid tert-butyl ester;18-Hydroxy-19-norcorticosterone;18-OH-19-NC;

Suppliers and Price of HO-PEG5-tBu

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Hydroxy-PEG5-t-butyl ester
1g
$ 626.00

Sigma-Aldrich
Hydroxy-PEG5-t-butyl ester
250mg
$ 216.00

purepeg
HO-PEG5-CH2CH2COOtBu min.95%
1 g
$ 132.30

ChemPep
HO-PEG5-tBu
25g
$ 1347.00

ChemPep
HO-PEG5-tBu
5g
$ 555.00

BroadPharm
Hydroxy-PEG5-t-butyl ester 98%
10 G
$ 825.00

Ambeed
tert-Butyl1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate 95%
1g
$ 230.00

Ambeed
tert-Butyl1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate 95%
5g
$ 688.00

Ambeed
tert-Butyl1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate 95%
250mg
$ 89.00

Ambeed
tert-Butyl1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate 95%
100mg
$ 68.00

Total 16 raw suppliers

Chemical Property of HO-PEG5-tBu

Chemical Property:

Refractive Index:n/D 1.448
Boiling Point:445.4±40.0 °C(Predicted)
PKA:14.36±0.10(Predicted)
PSA：92.68000
Density:1.071
LogP:0.79350
Storage Temp.:-20°C

Purity/Quality:

97% ^*data from raw suppliers

Hydroxy-PEG5-t-butyl ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Hydroxy-PEG5-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Technology Process of HO-PEG5-tBu

There total 2 articles about HO-PEG5-tBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4792-15-8
Pentaethylene glycol

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 850090-09-4,892154-71-1
18-hydroxy-4,7,10,13,16-pentaoxaoctadecanoic acid tert-butyl ester

Guidance literature:: Pentaethylene glycol; With sodium; In tetrahydrofuran; for 1.5h;

tert-Butyl acrylate; In tetrahydrofuran;
DOI:10.1021/ja043134b