Aspirin phenylalanine

Base Information

• Chemical Name: Aspirin phenylalanine
• CAS No.: 80639-96-9
• Molecular Formula: C₁₈H₁₇NO₅
• Molecular Weight: 327.337
• Mol file: 80639-96-9.mol

Synonyms:

Chemical Property of Aspirin phenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Aspirin phenylalanine

There total 6 articles about Aspirin phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

L-phenylalanine sodium salt (16480-57-2) + acetylsalicylic acid N-hydroxysuccinimide ester (84388-73-8) → aspirin phenylalanine (80639-96-9)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1007/s10600-006-0079-5

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → aspirin phenylalanine (80639-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.9 g / SOCl₂ / 2 h / Heating

2: 1.) dicyclohexylcarbodiimide, 2.) Et₃N / 1.) CH₂Cl₂, room temperature, 2 h, 2.) room temperature, overnight

3: ethanol / 0.03 h / pH 7.5 phosphate buffer, α-chymotrypsin

With thionyl chloride; triethylamine; dicyclohexyl-carbodiimide; In ethanol;

DOI:10.1002/jps.2600701202

Reference yield:

(L)-phenylalanine ethyl ester hydrochloride (3182-93-2) → aspirin phenylalanine (80639-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) dicyclohexylcarbodiimide, 2.) Et₃N / 1.) CH₂Cl₂, room temperature, 2 h, 2.) room temperature, overnight

2: ethanol / 0.03 h / pH 7.5 phosphate buffer, α-chymotrypsin

With triethylamine; dicyclohexyl-carbodiimide; In ethanol;

DOI:10.1002/jps.2600701202

upstream raw materials:

aspirin phenylalanine ethyl ester

L-phenylalanine sodium salt

acetylsalicylic acid N-hydroxysuccinimide ester

L-phenylalanine