29-Methylidene-2,3-oxidosqualene

Base Information

Chemical Name:29-Methylidene-2,3-oxidosqualene
CAS No.:145919-42-2
Molecular Formula:C₃₁H₅₀O
Molecular Weight:438.737
Hs Code.:
Wikidata:Q27071878
Pharos Ligand ID:5RG4GPATT49N

Synonyms:(3H)29-MOS;29-methylidene-2,3-oxidosqualene;29-MOS

Suppliers and Price of 29-Methylidene-2,3-oxidosqualene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 29-Methylidene-2,3-oxidosqualene

Chemical Property:

Vapor Pressure:2.9E-10mmHg at 25°C
Boiling Point:516.5°Cat760mmHg
Flash Point:251.8°C
PSA：12.53000
Density:0.885g/cm³
LogP:9.98230
XLogP3:10.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:17
Exact Mass:438.386166214
Heavy Atom Count:32
Complexity:696

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC=CCCC(=CCCC(=CCCC=C(C)CCC=C(C)CCC1C(O1)(C)C)C)CC=C
Isomeric SMILES:C/C=C\CC/C(=C\CC/C(=C/CC/C=C(\C)/CC/C=C(\C)/CCC1C(O1)(C)C)/C)/CC=C

Technology Process of 29-Methylidene-2,3-oxidosqualene

There total 56 articles about 29-Methylidene-2,3-oxidosqualene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56882-09-8
(4E,8E,12E)-4,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraen-1-al

: 137846-76-5,145919-42-2
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / p-TsOH*H₂O / benzene / 4 h / Heating

2: 41 percent / aq. NBS / tetrahydrofuran / 0.25 h / 0 °C

3: 72 percent / PdCl₂(CH₃CN)2 / acetone / 8 h

4: 73 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

5: 1.) 18-crown-6, <(CH₃)3Si>2NK / 1.) THF, toluene, -80 deg C, 30 min, 2.) THF, toluene, a) -80 deg C, 2 h, b) -40 deg C, 15 min

6: 94 percent / LiAlH₄ / diethyl ether / 0.5 h / -30 °C

7: 88 percent / Na₂CO₃, MnO₂ / hexane / 4 h / 5 °C

8: 1.) n-BuLi / 1.) THF, hexane, -20 deg C, 30 min, 2.) THF, hexane, a) -80 deg C, 30 min, b) RT, 30 min

With manganese(IV) oxide; dichloro bis(acetonitrile) palladium(II); N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; 18-crown-6 ether; potassium hexamethylsilazane; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; hexane; acetone; benzene;
DOI:10.1021/jm970534j

Reference yield:

: 137846-80-1
(2Z,6E,10E,14E)-18,19-epoxy-6,11,15,19-tetramethyl-2-(4-methyl-3-pentenyl)-2,6,10,14-icosatetraen-1-ol

: 137846-76-5,145919-42-2
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Na₂CO₃, MnO₂ / hexane / 4 h / 5 °C

2: 1.) n-BuLi / 1.) THF, hexane, -20 deg C, 30 min, 2.) THF, hexane, a) -80 deg C, 30 min, b) RT, 30 min

With manganese(IV) oxide; n-butyllithium; sodium carbonate; In hexane;
DOI:10.1021/jm970534j

Reference yield:

: 111-02-4
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene

: 137846-76-5,145919-42-2
(6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / H₅IO₆ / tetrahydrofuran; H₂O / 10 h / 0 - 20 °C

2: 96 percent / KN(TMS)2, 18-crown-6- / 2 h / -78 °C

3: LiAlH₄ / 1 h / 0 °C

4: 11 percent / N-bromosuccinimide / tetrahydrofuran; H₂O / 3 h / 0 °C

5: K₂CO₃ / methanol / 0.5 h / 20 °C

6: MnO₂, Na₂CO₃ / hexane / 35 h / 20 °C

7: 1 h / -78 - 0 °C

With manganese(IV) oxide; N-Bromosuccinimide; lithium aluminium tetrahydride; 18-crown-6 ether; potassium hexamethylsilazane; sodium carbonate; potassium carbonate; periodic acid; In tetrahydrofuran; methanol; hexane; water;
DOI:10.1021/ja00025a043