56882-09-8

Basic information

• Product Name: (4E,8E,12E)-4,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraen-1-al
• Synonyms: (4E,8E,12E)-4,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraen-1-al
• CAS NO: 56882-09-8
• Molecular Weight: 316.527
• Mol File: 56882-09-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4E,8E,12E)-4,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraen-1-al(CAS DataBase Reference)
• NIST Chemistry Reference: (4E,8E,12E)-4,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraen-1-al(56882-09-8)
• EPA Substance Registry System: (4E,8E,12E)-4,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraen-1-al(56882-09-8)

Safety Data

• Hazardous Substances Data: 56882-09-8(Hazardous Substances Data)

Upstream product

• 111-02-4 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene 

Downstream Products

• 784182-89-4 ((6E,10E,14E,18E)-2,10,15,19,23-Pentamethyl-tetracosa-2,6,10,14,18,22-hexaene-4-sulfonyl)-benzene 
• 118198-35-9 threo-(6E,10E,14E)-2-diphenylphosphinoyl-18,19-epoxy-2-isopentyloxy-6,11,15,19-tetramethylicosa-6,10,14-trien-3-ol 
• 118198-35-9 erithro-(6E,10E,14E)-2-diphenylphosphinoyl-18,19-epoxy-2-isopentyloxy-6,11,15,19-tetramethylicosa-6,10,14-trien-3-ol 
• 145919-42-2 (6E,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene 
• 137846-76-5 (6Z,10E,14E,18E)-22,23-epoxy-2,10,15,19,23-pentamethyl-6-vinyl-2,6,10,14,18-tetracosapentaene 
• 784182-85-0 ((6E,10E,14E,18E)-2,7,10,15,19,23-Hexamethyl-tetracosa-2,6,10,14,18,22-hexaene-4-sulfonyl)-benzene 
• 854735-54-9 (6E,10E,14E)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6,11,15,19-tetramethyl-icosa-1,6,10,14,18-pentaen-3-ol 

Relevant articles and documents

2,3-Epoxy-10-aza-10,11-dihydrosqualene, a High-Energy Intermediate Analogue Inhibitor of 2,3-Oxidosqualene Cyclase

2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-xidosqualene (SO) cyclase was obtained by total synthesis.This involved the preparation of three main building blocks: (1) C17 squalenoid N-methylamine, (2) 3-(diphenylphosphinoyl)propanal, and (3) 5,6-epoxy-6-methylheptan-2-one.The final stages of the reconstruction of the 6E double bond were obtained by a Wittig-Horner reaction which was modified for poorly reactive systems.This compound was designed to mimic the C-8 carbonium ion formed during SO cyclization.Its inhibitory activity on various SO cyclases was evaluated and compared with the 6 Z isomer which has an unfavorable geometry.Only isomer 6 E, the carbocation analogue, was active on SO cyclases from rat liver, pig liver, S. cerevisiae, and C. albicans microsomes, with an I50 varying from 3 to 5 μM.Both E and Z isomers were inactive on squalene epoxidase at the higher concentrations tested.