1,2,5-Oxadiazol-3-amine, 4-[1-[4-(4-piperidinyloxy)phenyl]-1H-imidazo[4,5-c]pyridin-2-yl]-

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Chemical Name:1,2,5-Oxadiazol-3-amine, 4-[1-[4-(4-piperidinyloxy)phenyl]-1H-imidazo[4,5-c]pyridin-2-yl]-
CAS No.:850850-68-9
Molecular Formula:C19H19N7O2
Molecular Weight:377.406
Hs Code.:

Synonyms:

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Chemical Property of 1,2,5-Oxadiazol-3-amine, 4-[1-[4-(4-piperidinyloxy)phenyl]-1H-imidazo[4,5-c]pyridin-2-yl]-

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Technology Process of 1,2,5-Oxadiazol-3-amine, 4-[1-[4-(4-piperidinyloxy)phenyl]-1H-imidazo[4,5-c]pyridin-2-yl]-

There total 5 articles about 1,2,5-Oxadiazol-3-amine, 4-[1-[4-(4-piperidinyloxy)phenyl]-1H-imidazo[4,5-c]pyridin-2-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 850850-61-2
1,1-dimethylethyl 4-({4-[2-(4-amino-furazan-3-yl)-1H-imidazo[4,5-c]pyridin-1-yl]phenyl}oxy)-1-piperidinecarboxylate

: 850850-68-9
4-{1-[4-(4-piperidinyloxy)phenyl]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

Guidance literature:: With trifluoroacetic acid; In methanol; at 20 ℃; for 1h;

Reference yield:

: 5435-54-1
4-hydroxy-3-nitropyridine

: 850850-68-9
4-{1-[4-(4-piperidinyloxy)phenyl]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / toluene / 16 h / 0 - 110 °C / Heating / reflux

2.1: sodium hydrogencarbonate / tetrahydrofuran; ethanol / 2 h / 20 - 80 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 2585.81 Torr

4.1: 0.42 h / 195 °C

5.1: hydrogenchloride; sodium nitrite / methanol; water / 1.5 h / 20 °C

5.2: 16 h / 110 °C / pH 11

6.1: boron tribromide / dichloromethane / 16 h / 0 - 20 °C

6.2: pH 14

7.1: di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine / 1,4-dioxane / 12 h / 80 °C

8.1: trifluoroacetic acid / methanol / 1 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine; hydrogen; boron tribromide; sodium hydrogencarbonate; trifluoroacetic acid; sodium nitrite; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene;

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 850850-68-9
4-{1-[4-(4-piperidinyloxy)phenyl]-1H-imidazo[4,5-c]pyridin-2-yl}-furazan-3-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; ethanol / 2 h / 20 - 80 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 2585.81 Torr

3.1: 0.42 h / 195 °C

4.1: hydrogenchloride; sodium nitrite / methanol; water / 1.5 h / 20 °C

4.2: 16 h / 110 °C / pH 11

5.1: boron tribromide / dichloromethane / 16 h / 0 - 20 °C

5.2: pH 14

6.1: di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine / 1,4-dioxane / 12 h / 80 °C

7.1: trifluoroacetic acid / methanol / 1 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; polymer-bound triphenylphosphine; hydrogen; boron tribromide; sodium hydrogencarbonate; trifluoroacetic acid; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;