Quinazoline, 4-((2-(dimethylamino)ethyl)amino)-

Base Information

• Chemical Name: Quinazoline, 4-((2-(dimethylamino)ethyl)amino)-
• CAS No.: 3337-87-9
• Molecular Formula: C12H16N4
• Molecular Weight: 216.2822
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00186994
• Nikkaji Number: J48.178E
• Wikidata: Q83058486
• ChEMBL ID: CHEMBL1624896
• Mol file: 3337-87-9.mol

Synonyms:4-Dimethyl aminoethyl amino quinazoline;Quinazoline, 4-((2-(dimethylamino)ethyl)amino)-;3337-87-9;BRN 0746606;SU-13026;N,N-Dimethyl-N'-quinazolin-4-yl-ethane-1,2-diamine;MLS000031555;Quinazoline, 4-[[2-(dimethylamino)ethyl]amino]-;SMR000010337;Oprea1_599682;Oprea1_673088;CHEMBL1624896;BDBM39575;cid_2789306;DTXSID00186994;HMS1680N16;STK969982;AKOS000536813;4-[2-(Dimethylamino)ethylamino]quinazoline;LS-140100;1,2-Ethanediamine, N,N-dimethyl-N'-4-quinazolinyl-;N,N-dimethyl-N'-(quinazolin-4-yl)ethane-1,2-diamine;dimethyl-[2-(quinazolin-4-ylamino)ethyl]amine;hydrochloride;N'',N''-dimethyl-N-quinazolin-4-ylethane-1,2-diamine;N'',N''-dimethyl-N-(4-quinazolinyl)ethane-1,2-diamine;N'',N''-dimethyl-N-quinazolin-4-yl-ethane-1,2-diamine

Chemical Property of Quinazoline, 4-((2-(dimethylamino)ethyl)amino)-

Chemical Property:

• Boiling Point: 373.6°Cat760mmHg
• Flash Point: 179.7°C
• PSA: 44.28000
• Density: 1.161g/cm³
• LogP: 1.02520
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 216.137496527
• Heavy Atom Count: 16
• Complexity: 207

Purity/Quality:

DIMETHYL[2-(QUINAZOLIN-4-YLAMINO)ETHYL]AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCNC1=NC=NC2=CC=CC=C21

Technology Process of Quinazoline, 4-((2-(dimethylamino)ethyl)amino)-

There total 3 articles about Quinazoline, 4-((2-(dimethylamino)ethyl)amino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-quinazolinol (491-36-1,134434-33-6) → N,N-dimethyl-N'-quinazolin-4-yl-ethane-1,2-diamine (3337-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorous oxychloride / 3 h / 100 °C

2: CH₂Cl₂ / 4 h / Heating

With trichlorophosphate; In dichloromethane;

DOI:10.1515/HC.2004.10.4-5.269

Reference yield:

4-chloroquinazoline (5190-68-1) + N,N-dimethylethylenediamine (108-00-9) → N,N-dimethyl-N'-quinazolin-4-yl-ethane-1,2-diamine (3337-87-9)

Guidance literature:

In dichloromethane; for 4h; Heating;

DOI:10.1515/HC.2004.10.4-5.269

Reference yield:

→ N,N-dimethyl-N'-quinazolin-4-yl-ethane-1,2-diamine (3337-87-9)

Guidance literature:

aus d. 4-SH-Verb. u. Amin;

upstream raw materials:

4-chloroquinazoline

N,N-dimethylethylenediamine

4-quinazolinol

Refernces