Technology Process of Phosphine,
[[2-[[bis(4-methoxyphenyl)phosphino]methyl]phenyl]methyl]diphenyl-
There total 2 articles about Phosphine,
[[2-[[bis(4-methoxyphenyl)phosphino]methyl]phenyl]methyl]diphenyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
bis(4-methoxyphenyl)phosphine;
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium;
In
tetrahydrofuran; hexane;
at 25 ℃;
for 0.5h;
1,5-dihydro-benzo[e][1,3,2]dioxathiepine 3,3-dioxide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 1h;
lithium diphenylphosphide;
In
tetrahydrofuran; hexane;
at 60 ℃;
for 3h;
DOI:10.1002/hlca.200590002
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: SOCl2 / CCl4 / 1.5 h / Heating
1.2: 72 percent / RuCl3*nH2O; NaIO4 / CCl4; acetonitrile; H2O / 1 h / 25 °C
2.1: BuLi; hexamethylphosphoramide / hexane; tetrahydrofuran / 0.5 h / 25 °C
2.2: hexane; tetrahydrofuran / 1 h / -78 - 20 °C
2.3: 56 percent / hexane; tetrahydrofuran / 3 h / 60 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; thionyl chloride;
In
tetrahydrofuran; tetrachloromethane; hexane;
DOI:10.1002/hlca.200590002
- Guidance literature:
-
In
dichloromethane;
(N2 or Ar); using Schlenk techniques; addn. of soln. of (4-CH3OC6H4)2PCH2C6H4CH2PPh2 (1.1-1.2 equiv.) in CH2Cl2 to soln. of PdCH3(COD)Cl (1 equiv.) in CH2Cl2; stirring for 3 h at room temp. (J. Chem. Soc. (1957) 3413); (Inorg. Chem. 32 (1993) 5769); evapn.; pptn. by addn. n-pentane; washing with n-pentane and drying under HV; as mixt. of 2 isomers; elem. anal.;
DOI:10.1016/j.jorganchem.2006.06.038
