cyclopropyl(4-nitrophenyl)sulfane

Base Information

• Chemical Name: cyclopropyl(4-nitrophenyl)sulfane
• CAS No.: 851008-48-5
• Molecular Formula: C9H9NO2S
• Molecular Weight: 195.242
• Mol file: 851008-48-5.mol

Synonyms:cyclopropyl(4-nitrophenyl)sulfane;

Chemical Property of cyclopropyl(4-nitrophenyl)sulfane

Chemical Property:

• PSA: 71.12000
• LogP: 3.37250
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Cyclopropyl(4-nitrophenyl)sulfane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclopropyl(4-nitrophenyl)sulfane

There total 4 articles about cyclopropyl(4-nitrophenyl)sulfane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

para-nitrobenzenethiol (1849-36-1) + cyclopropylboronic acid (411235-57-9) → 1-(cyclopropylsulphanyl)-4-nitrobenzene (851008-48-5)

Guidance literature:

With [2,2]bipyridinyl; copper diacetate; caesium carbonate; In 1,2-dichloro-ethane; at 70 ℃; for 16h; Sealed tube;

DOI:10.3762/bjoc.15.113

Reference yield: 75.0%

tricyclopropylbismuthane (925430-09-7) + para-nitrobenzenethiol (1849-36-1) → 1-(cyclopropylsulphanyl)-4-nitrobenzene (851008-48-5) + di(p-nitrophenyl) disulfide (100-32-3)

Guidance literature:

With pyridine; copper diacetate; In dichloromethane; at 50 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.jorganchem.2019.04.032

Reference yield: 61.0%

cyclopropanethiol (6863-32-7) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-(cyclopropylsulphanyl)-4-nitrobenzene (851008-48-5)

Guidance literature:

cyclopropanethiol; With sodium hydride; In tetrahydrofuran; diethyl ether; mineral oil; at 20 ℃; for 0.5h;

4-Fluoronitrobenzene; In tetrahydrofuran; diethyl ether; mineral oil; at 40 ℃; for 2h;

upstream raw materials:

cyclopropanethiol

4-Fluoronitrobenzene

cyclopropyl bromide

para-nitrobenzenethiol

Downstream raw materials:

4-(cyclopropylsulfonyl)aniline

(2R,3R)-3-[2-(4-Cyclopropanesulphonylphenylamino)-5-trifluoromethylpyrimidin-4-yloxy]butan-2-ol

1-(cyclopropylsulfonyl)-4-nitrobenzene

[4-((1R,2R)-2-Benzyloxy-1-methylpropoxy)-5-trifluoromethylpyrimidin-2-yl](4-cyclopropane-sulphonylphenyl)amine

Refernces

• 1、 Benoit, Emeline,Fnaiche, Ahmed,Gagnon, Alexandre. "Synthesis of aryl cyclopropyl sulfides through copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid". . p. 1162 - 1171. Retrieved 2019/06/08.
• 2、 -. "PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION". Paragraph 0138-0144. . Retrieved 2013/09/26.