3H-Fluoren-3-one, 7-amino-4-bromo-1,2,9,9a-tetrahydro-8-methyl-9a-(phenylmethyl)-

Base Information

Chemical Name:3H-Fluoren-3-one, 7-amino-4-bromo-1,2,9,9a-tetrahydro-8-methyl-9a-(phenylmethyl)-
CAS No.:851107-79-4
Molecular Formula:C21H20BrNO
Molecular Weight:382.3
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3H-Fluoren-3-one, 7-amino-4-bromo-1,2,9,9a-tetrahydro-8-methyl-9a-(phenylmethyl)-

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Technology Process of 3H-Fluoren-3-one, 7-amino-4-bromo-1,2,9,9a-tetrahydro-8-methyl-9a-(phenylmethyl)-

There total 9 articles about 3H-Fluoren-3-one, 7-amino-4-bromo-1,2,9,9a-tetrahydro-8-methyl-9a-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 851107-78-3
N-(9a-benzyl-4-bromo-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide

: 851107-79-4
N-(9a-benzyl-4-bromo-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide

Guidance literature:: With sodium methylate; In methanol; ethanol; at 80 ℃; for 6.5h;
DOI:10.1021/jm060516e

Reference yield:

: 429682-70-2
N-(4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

: 851107-79-4
N-(9a-benzyl-4-bromo-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / NaOMe / ethanol; methanol / 6 h / 20 °C

2: 77 percent / H₂ / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure

3: sodium methoxide / methanol / 19 h / 20 °C

4: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C

5: 100 percent / NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

6: 75 percent / sodium methoxide / ethanol; methanol / 6.5 h / 80 °C

With pyrrolidine; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm060516e

Reference yield:

: 429682-68-8
N-(4-bromo-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

: 851107-79-4
N-(9a-benzyl-4-bromo-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / dichlorobis(triphenylphosphine)-palladium(II); triphenylphosphine; lithium chloride / dimethylformamide / 6 h / 100 °C

2: 74 percent / NaOMe / ethanol; methanol / 6 h / 20 °C

3: 77 percent / H₂ / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure

4: sodium methoxide / methanol / 19 h / 20 °C

5: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C

6: 100 percent / NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

7: 75 percent / sodium methoxide / ethanol; methanol / 6.5 h / 80 °C

With pyrrolidine; bis-triphenylphosphine-palladium(II) chloride; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; acetic acid; triphenylphosphine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Stille coupling;
DOI:10.1021/jm060516e