Technology Process of N-(9a-benzyl-4-bromo-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide
There total 8 articles about N-(9a-benzyl-4-bromo-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bromine; sodium hydrogencarbonate;
In
dichloromethane;
at 0 ℃;
for 0.25h;
DOI:10.1021/jm060516e
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 74 percent / NaOMe / ethanol; methanol / 6 h / 20 °C
2: 77 percent / H2 / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure
3: sodium methoxide / methanol / 19 h / 20 °C
4: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C
5: 100 percent / NaHCO3; Br2 / CH2Cl2 / 0.25 h / 0 °C
With
pyrrolidine; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm060516e
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 72 percent / dichlorobis(triphenylphosphine)-palladium(II); triphenylphosphine; lithium chloride / dimethylformamide / 6 h / 100 °C
2: 74 percent / NaOMe / ethanol; methanol / 6 h / 20 °C
3: 77 percent / H2 / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure
4: sodium methoxide / methanol / 19 h / 20 °C
5: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C
6: 100 percent / NaHCO3; Br2 / CH2Cl2 / 0.25 h / 0 °C
With
pyrrolidine; bis-triphenylphosphine-palladium(II) chloride; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; acetic acid; triphenylphosphine; lithium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
1: Stille coupling;
DOI:10.1021/jm060516e
