Acetic acid, [4-[[4-(methoxymethoxy)-3-(1-methylethyl)-5-[[4-[[[tris(1-methylethyl)silyl] oxy]methyl]phenyl]ethynyl]phenyl]methyl]-3,5-dimethylphenoxy]-, methyl ester

Base Information

Chemical Name:Acetic acid, [4-[[4-(methoxymethoxy)-3-(1-methylethyl)-5-[[4-[[[tris(1-methylethyl)silyl] oxy]methyl]phenyl]ethynyl]phenyl]methyl]-3,5-dimethylphenoxy]-, methyl ester
CAS No.:851227-35-5
Molecular Formula:C41H56O6Si
Molecular Weight:672.978
Hs Code.:

Acetic acid,
[4-[[4-(methoxymethoxy)-3-(1-methylethyl)-5-[[4-[[[tris(1-methylethyl)silyl]
oxy]methyl]phenyl]ethynyl]phenyl]methyl]-3,5-dimethylphenoxy]-, methyl
ester

Synonyms:

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Chemical Property of Acetic acid, [4-[[4-(methoxymethoxy)-3-(1-methylethyl)-5-[[4-[[[tris(1-methylethyl)silyl] oxy]methyl]phenyl]ethynyl]phenyl]methyl]-3,5-dimethylphenoxy]-, methyl ester

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Technology Process of Acetic acid, [4-[[4-(methoxymethoxy)-3-(1-methylethyl)-5-[[4-[[[tris(1-methylethyl)silyl] oxy]methyl]phenyl]ethynyl]phenyl]methyl]-3,5-dimethylphenoxy]-, methyl ester

There total 8 articles about Acetic acid, [4-[[4-(methoxymethoxy)-3-(1-methylethyl)-5-[[4-[[[tris(1-methylethyl)silyl] oxy]methyl]phenyl]ethynyl]phenyl]methyl]-3,5-dimethylphenoxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 851227-22-0
(4-ethynylbenzyloxy)triisopropylsilane

: 446312-35-2
[4-(3-iodo-5-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester

: 851227-35-5
(4-{3-isopropyl-4-methoxymethoxy-5-[4-(triisopropylsilanyloxymethyl)phenylethynyl]benzyl}-3,5-dimethylphenoxy)acetic acid methyl ester

Guidance literature:: (4-ethynylbenzyloxy)triisopropylsilane; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h;

With 9-methoxy-9-BBN; In tetrahydrofuran; hexane; toluene; at -78 ℃; for 2h;

[4-(3-iodo-5-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester; With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; toluene; for 18h; Heating;
DOI:10.1021/ja0440093

Reference yield:

: 863640-77-1
((4-iodobenzyl)oxy)triisopropylsilane

: 851227-35-5
(4-{3-isopropyl-4-methoxymethoxy-5-[4-(triisopropylsilanyloxymethyl)phenylethynyl]benzyl}-3,5-dimethylphenoxy)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.18 g / PdCl₂(PPh₃)2; CuI; diethylamine / 5 h / 20 °C

2.1: 97 percent / aq. KOH / methanol / 2 h / 20 °C

3.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

3.2: methoxy-9-BBN / tetrahydrofuran; toluene; hexane / 2 h / -78 °C

3.3: 69 percent / PdCl₂(PPh₃)2 / tetrahydrofuran; toluene; hexane / 18 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; copper(l) iodide; potassium hexamethylsilazane; diethylamine; In tetrahydrofuran; methanol; toluene; 1.1: Sonogashira coupling / 3.3: Suzuki-Miyaura coupling;
DOI:10.1021/ja0440093

Reference yield:

: 863640-78-2
1-triisopropylsilanyloxymethyl-4-trimethylsilanylethynyl-benzene

: 851227-35-5
(4-{3-isopropyl-4-methoxymethoxy-5-[4-(triisopropylsilanyloxymethyl)phenylethynyl]benzyl}-3,5-dimethylphenoxy)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / aq. KOH / methanol / 2 h / 20 °C

2.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

2.2: methoxy-9-BBN / tetrahydrofuran; toluene; hexane / 2 h / -78 °C

2.3: 69 percent / PdCl₂(PPh₃)2 / tetrahydrofuran; toluene; hexane / 18 h / Heating

With potassium hydroxide; potassium hexamethylsilazane; In tetrahydrofuran; methanol; toluene; 2.3: Suzuki-Miyaura coupling;
DOI:10.1021/ja0440093