446312-35-2Relevant academic research and scientific papers
Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity
Singh, Latika,Pressly, Brandon,Mengeling, Brenda J.,Fettinger, James C.,Furlow, J. David,Lein, Pamela J.,Wulff, Heike,Singh, Vikrant
, p. 1870 - 1876 (2016/03/15)
We have synthesized and established the structure of a long-suspected, but hitherto unknown, benzofuran side product (EBI) formed during the synthesis of NH-3. Understanding the mechanism of its formation has enabled isotope (D) labeling. We further devel
Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists
Nguyen, Ngoc-Ha,Apriletti, James W.,Baxter, John D.,Scanlan, Thomas S.
, p. 4599 - 4608 (2007/10/03)
Selective thyroid hormone modulators that function as isoform-selective agonists or antagonists of the thyroid hormone receptors (TRs) might be therapeutically useful in diseases associated with aberrant hormone signaling. The most potent thyroid hormone
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment
Nguyen, Ngoc-Ha,Apriletti, James W.,Cunha Lima, Suzana T.,Webb, Paul,Baxter, John D.,Scanlan, Thomas S.
, p. 3310 - 3320 (2007/10/03)
Recent efforts have focused on the design and synthesis of thyroid hormone (T3) antagonists as potential therapeutic agents and chemical probes to understand hormone-signaling pathways. We previously reported the development of novel first-gene
