446312-35-2

Upstream product

• 328236-45-9 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol 
• 328236-44-8 2,6-dimethyl-4-(triisopropyl-silanyloxy)-benzaldehyde 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 328236-42-6 4-bromo-2-isopropyl phenyl methoxymethyl ether 
• 26307-50-6 4-bromo-2-isopropyl-phenol 
• 88-69-7 2-(1-methylethyl)phenol 
• 446312-28-3 [4-(3-iodo-5-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]triisopropylsilane 
• 328236-46-0 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)-O-triisopropylsilylphenol 
• 328236-47-1 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenol 
• 851227-20-8 [4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester 
• 863639-45-6 methyl 2-(4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetate 
• 851227-21-9 [4-(4-hydroxy-3-iodo-5-isopropylbenzyl)-3,5-dimethylphenoxy]acetic acid methyl ester 
• 107-30-2 chloromethyl methyl ether 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 851227-23-1 {4-[3-isopropyl-4-methoxymethoxy-5-(4-trifluoromethylphenylethynyl)benzyl]-3,5-dimethylphenoxy}acetic acid methyl ester 
• 851227-27-5 4-[3-isopropyl-5-(4-methoxycarbonylmethoxy-2,6-dimethylbenzyl)-2-methoxymethoxyphenylethynyl]-benzoic acid methyl ester 
• 851227-29-7 {4-[3-(4-dimethylaminophenylethynyl)-5-isopropyl-4-methoxymethoxybenzyl]-3,5-dimethylphenoxy}acetic acid methyl ester 
• 863640-02-2 {4-[3-(4-fluoro-phenylethynyl)-4-hydroxy-5-isopropyl-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 863640-11-3 {4-[3-(2-amino-phenylethynyl)-4-hydroxy-5-isopropyl-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 863640-00-0 {4-[4-hydroxy-3-isopropyl-5-(4-methoxy-phenylethynyl)-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 863640-46-4 {4-[3-(4-azido-phenylethynyl)-4-hydroxy-5-isopropyl-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 863640-01-1 {4-[3-(4-cyano-phenylethynyl)-4-hydroxy-5-isopropyl-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 851227-51-5 {4-[3-(3-aminophenylethynyl)-4-hydroxy-5-isopropylbenzyl]-3,5-dimethylphenoxy}acetic acid methyl ester 
• 863642-22-2 {4-[4-hydroxy-3-isopropyl-5-(3-nitro-phenylethynyl)-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 863640-05-5 {4-[3-(4-dimethylamino-phenylethynyl)-4-hydroxy-5-isopropyl-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 863640-03-3 4-[2-hydroxy-3-isopropyl-5-(4-methoxycarbonylmethoxy-2,6-dimethyl-benzyl)-phenylethynyl]-benzoic acid methyl ester 
• 863641-31-0 {4-[3-(4-azidomethyl-phenylethynyl)-4-hydroxy-5-isopropyl-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 863640-99-7 {4-[3-(4-hydroxymethyl-phenylethynyl)-5-isopropyl-4-methoxymethoxy-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 

Relevant academic research and scientific papers

Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity

We have synthesized and established the structure of a long-suspected, but hitherto unknown, benzofuran side product (EBI) formed during the synthesis of NH-3. Understanding the mechanism of its formation has enabled isotope (D) labeling. We further devel

Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists

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Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment

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